秦竹凉血汤治疗特应性皮炎的疗效和安全性：一项随机对照试验。
Efficacy and safety of Qinzhuliangxue decoction for treating atopic eczema: a randomized controlled trial.
机构信息
Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China; Department of Surgery of Traditional Chinese Medicine, Xiangshan Traditional Chinese Medicine Hospital, Shanghai 200020, China.
出版信息
Ann Palliat Med. 2020 May;9(3):870-882. doi: 10.21037/apm.2020.04.17. Epub 2020 Apr 26.
BACKGROUND
Atopic eczema is the most common type of skin disorder in both children and adults. It is characterized by erythema, pruritus, papules, xeransis, and lichenification. Qinzhuliangxue decoction (QZLXD), a Chinese herbal medicine (CHM) prepared with several ingredients that are used to treat eczema, was formulated according to the traditional Chinese medicine (TCM) theory. This study aimed to investigate the efficacy and safety of QZLXD administration for treating atopic eczema compared to those of Runzaozhiyang capsules (RZZYC).
METHODS
A total of 176 patients were enrolled at the Shanghai Yueyang Hospital and were randomly assigned to the QZLXD treatment group (n=82) or the RZZYC control group (n=86). The differences in Eczema Area and Severity Index (EASI), Dermatology Life Quality Index, itching score, recurrence rate, and adverse events (AEs) were compared between the groups.
RESULTS
The EASI score (x2=14.181, P=0.003), recurrence rate (x2=7.398, P=0.007), and itching score (F=-3.427, P=0.001) were lower in the QZLXD group than in the RZZYC group. Incidence of AEs was similar between the RZZYC and QZLXD groups (P=0.434).
CONCLUSIONS
QZLXD is recommended for the treatment of subacute atopic eczema because QZLXD showed good efficiency with low recurrence rate and tolerable AEs.
背景
特应性皮炎是儿童和成人中最常见的皮肤疾病类型。其特征为红斑、瘙痒、丘疹、干燥和苔藓样变。芩竹凉血汤（QZLXD）是一种中药（CHM），由几种用于治疗湿疹的成分组成，是根据中医（TCM）理论配方而成。本研究旨在比较 QZLXD 给药与润燥止痒胶囊（RZZYC）治疗特应性皮炎的疗效和安全性。
方法
共有 176 名患者在上海岳阳医院就诊，被随机分配到 QZLXD 治疗组（n=82）或 RZZYC 对照组（n=86）。比较两组患者的湿疹面积和严重程度指数（EASI）、皮肤病生活质量指数、瘙痒评分、复发率和不良反应（AE）的差异。
结果
QZLXD 组的 EASI 评分（x2=14.181，P=0.003）、复发率（x2=7.398，P=0.007）和瘙痒评分（F=-3.427，P=0.001）均低于 RZZYC 组。RZZYC 组和 QZLXD 组的不良反应发生率相似（P=0.434）。
结论
推荐使用 QZLXD 治疗亚急性特应性皮炎，因为 QZLXD 显示出良好的疗效，复发率低，不良反应可耐受。
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