Bankova V V, Nikanorova T M, Poliakov S D, Tagieva T A
Vopr Med Khim. 1988 Nov-Dec;34(6):27-30.
A rate of malonic dialdehyde (MDA) degradation was studied in erythrocytes of newborns within the first and 4-5th days of life, of 5-6 and 8-14 years old children and of 18-28 and 35-49 years old adult persons by means of introduction of exogenous MDA into the mixture containing erythrocytes and estimation of the aldehyde elimination during incubation. Intensity of MDA degradation correlated with its content in erythrocytes. Age-, season- and circadian-dependent alterations were detected in the rate of MDA degradation as well as in the ratio of this value to the total content of MDA (index D/M). The lowest rate of MDA degradation and the index D/M value were observed in the persons of the older age group (35-49 years old). Either in 8-14 years old children or in adult persons the index D/M exhibited higher values in summer time as compared with other seasons. Distinct circadian alterations of the patterns studied were found in 18-28 years old persons but these patterns were dissimilarly directed during a day in newborns.
通过向含有红细胞的混合物中引入外源性丙二醛（MDA）并在孵育过程中评估醛的消除情况，研究了新生儿出生后第1天和第4 - 5天、5 - 6岁和8 - 14岁儿童以及18 - 28岁和35 - 49岁成年人红细胞中MDA的降解速率。MDA降解强度与其在红细胞中的含量相关。在MDA降解速率以及该值与MDA总含量的比值（指数D/M）中检测到了年龄、季节和昼夜节律依赖性变化。在年龄较大的人群（35 - 49岁）中观察到MDA降解速率和指数D/M值最低。在8 - 14岁儿童或成年人中，指数D/M在夏季时比其他季节更高。在18 - 28岁人群中发现了所研究模式的明显昼夜节律变化，但新生儿在一天中的这些模式方向不同。
