Stefano Marina A, Poderoso Rosana E, Mainz Jochen G, Ribeiro Jose D, Ribeiro Antonio F, Lomazi Elizete Aparecida
Universidade Estadual de Campinas, Centro de Referência em Fibrose Cística, Campinas, SP, Brazil.
Universidade Estadual de Campinas, Biblioteca da Faculdade de Ciências Médicas, Campinas, SP, Brazil.
J Pediatr (Rio J). 2020 Nov-Dec;96(6):686-692. doi: 10.1016/j.jped.2020.03.004. Epub 2020 May 8.
To systematically revise the literature in search of data about the prevalence of constipation in patients with cystic fibrosis according to the publications in this field, which partly refer to guidelines defined in 2010 by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
Systematic review selecting articles based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, including Cystic Fibrosis patients of all ages. Sources of information were selected to identify the articles without period limitation: CADTH - Canadian Agency for Drugs and Technologies in Health, CINAHL Complete, Clinical Trials US NIH, Cochrane Library, Embase, MEDLINE via Ovid, Scopus, Web Of Science, PubMed, SciELO, MEDLINE and LILACS , Health Systems Evidence, PDQ Evidence, CRD Canadian Agency for Drugs and Technologies in Health, INAHTA - International Network of Agencies for Health Technology Assessment, and PEDro.
The prevalence of constipation was reported in eight observational studies. Only two studies assessed the frequency of constipation as a primary objective; in the others, constipation was quoted along with the prevalence of the spectrum of gastrointestinal manifestations. Altogether, the publications included 2,018 patients, the reported prevalence varied from 10% to 57%. Only two of the six articles published after 2010 followed the definition recommended by the European Society.
Constipation is a frequent but still insufficiently assessed complaint of Cystic Fibrosis patients. The use of diverse diagnostic criteria restricts comparison and epidemiological conclusions, future studies should compulsorily apply the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition definition.
根据该领域的出版物，系统回顾文献以寻找有关囊性纤维化患者便秘患病率的数据，这些出版物部分参考了欧洲儿科胃肠病学、肝病学和营养学会2010年定义的指南。
基于系统评价和荟萃分析的首选报告项目进行系统评价，纳入所有年龄段的囊性纤维化患者。信息来源的选择旨在识别无时间限制的文章：加拿大卫生技术评估署（CADTH）、护理学与健康领域数据库（CINAHL Complete）、美国国立卫生研究院临床试验库、考克兰图书馆、荷兰医学文摘数据库（Embase）、通过Ovid检索的医学索引数据库（MEDLINE）、Scopus数据库、科学引文索引（Web Of Science）、美国国立医学图书馆医学文献数据库（PubMed）、拉丁美洲和加勒比地区卫生科学数据库（SciELO）、医学索引数据库（MEDLINE）和拉丁美洲及加勒比公共卫生数据库（LILACS）、卫生系统证据、PDQ证据、加拿大卫生技术评估署（CRD）、国际卫生技术评估机构网络（INAHTA）和循证医学数据库（PEDro）。
八项观察性研究报告了便秘的患病率。只有两项研究将便秘频率作为主要研究目标；在其他研究中，便秘与胃肠道表现谱的患病率一同被提及。这些出版物总共纳入了2018例患者，报告的患病率从10%到57%不等。2010年后发表的六篇文章中只有两篇遵循了欧洲学会推荐的定义。
便秘是囊性纤维化患者常见但评估仍不充分的主诉。不同诊断标准的使用限制了比较和流行病学结论，未来研究应强制采用欧洲儿科胃肠病学、肝病学和营养学会的定义。
