Department of Neurosurgery, West China Hospital, Chengdu, Sichuan Province, P. R. China.
Department of Neurosurgery, West China Hospital, Chengdu, Sichuan Province, P. R. China.
World Neurosurg. 2020 Jul;139:e700-e707. doi: 10.1016/j.wneu.2020.04.107. Epub 2020 May 7.
To assess the early mortality in pediatric glioma and identify predictors of early mortality, which may provide insight into the therapeutic strategies for children with a high risk of early mortality.
We used SEER∗Stat 8.3.5 software to extract data of pediatric glioma from the Surveillance, Epidemiology, and End Results database. Logistical regression to identify the independent factors in predicting early mortality.
A total of 3035 male and 2741 female patients were enrolled in the present study. The death rates within 1 month and 3 months after diagnosis were 1.32% and 2.44%, respectively. Early mortality decreased significantly during the past 40 years. Our results showed that glioblastoma, anaplastic glioma, and oligodendroglioma were risk factors of early mortality for children diagnosed with glioma, whereas advanced age, gross total resection, radiation, and chemotherapy were associated with decreased early mortality.
We found a decrease in early mortality during the past 40 years. The death rates within 1 month and 3 months after diagnosis were 1.32% and 2.44%, respectively. Age at diagnosis, histologic subtype, the extent of resection, chemotherapy, and radiation were associated with early mortality in pediatric glioma.
评估小儿脑胶质瘤的早期死亡率，并确定早期死亡的预测因素，这可能为高危患儿的治疗策略提供思路。
我们使用 SEER∗Stat 8.3.5 软件从监测、流行病学和最终结果数据库中提取小儿脑胶质瘤的数据。使用逻辑回归来确定预测早期死亡的独立因素。
本研究共纳入 3035 名男性和 2741 名女性患者。诊断后 1 个月和 3 个月的死亡率分别为 1.32%和 2.44%。在过去的 40 年中，早期死亡率显著下降。研究结果显示，胶质母细胞瘤、间变星形细胞瘤和少突胶质细胞瘤是儿童脑胶质瘤早期死亡的危险因素，而年龄较大、大体全切除、放疗和化疗与早期死亡率降低相关。
我们发现过去 40 年来早期死亡率有所下降。诊断后 1 个月和 3 个月的死亡率分别为 1.32%和 2.44%。诊断时的年龄、组织学亚型、切除程度、化疗和放疗与小儿脑胶质瘤的早期死亡有关。
