[1例HER2阳性胃癌伴多发肝转移经化疗后行根治性转化治疗的病例]
[A Case of HER2-Positive Gastric Cancer with Multiple Liver Metastases Treated with Curative Conversion Therapy after Chemotherapy].
作者信息
Kato Yukihiro, Natsuki Seiji, Iimori Nozomi, Okuno Tomohisa, Kametani Naoki, Noda Eiji, Yamamoto Atsushi, Yamada Nobuya, Nishimura Shigehiko, Taenaka Naoyuki, Matsunaga Yuki, Fujita Shigeki
机构信息
Dept. of Surgery, Sumitomo Hospital.
出版信息
Gan To Kagaku Ryoho. 2020 Apr;47(4):682-684.
A 66-year-old man underwent chemotherapy with S-1 plus cisplatin plus trastuzumab to treat advanced gastric cancer that was diagnosed as cStage Ⅳ adenocarcinoma(T3N1M1[P0, CYX, H1]). After 8 courses, liver metastases were absent on contrast-enhanced MRI. The patient underwent a laparoscopic distal gastrectomy with D2 lymphadenectomy. The gross appearance of the surgically resected specimen showed a shrunk gastric tumor measuring 1 mm. The postoperative course was uneventful, and the patient has been well, receiving maintenance chemotherapy of S-1 plus trastuzumab without evidence of recurrence for 15 months following the operation. Conversion surgery following chemotherapy might be an effective treatment for patients with advanced gastric cancer; however, further studies are needed to establish this treatment strategy.
一名66岁男性接受了S-1联合顺铂及曲妥珠单抗化疗，以治疗诊断为c期Ⅳ腺癌（T3N1M1[P0, CYX, H1]）的晚期胃癌。8个疗程后，对比增强MRI显示无肝转移。患者接受了腹腔镜远端胃癌根治术及D2淋巴结清扫术。手术切除标本的大体外观显示胃肿瘤缩小至1毫米。术后过程顺利，患者情况良好，术后15个月接受S-1联合曲妥珠单抗维持化疗，无复发迹象。化疗后进行转化手术可能是晚期胃癌患者的一种有效治疗方法；然而，需要进一步研究以确立这种治疗策略。
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