Byrne Christina, Kjaer Andreas, Olsen Naja Enevold, Forman Julie Lyng, Hasbak Philip
Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, 9841, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Department of Biomedical Sciences, Copenhagen University Hospital Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
J Nucl Cardiol. 2021 Dec;28(6):2860-2871. doi: 10.1007/s12350-020-02140-1. Epub 2020 May 10.
Myocardial flow reserve (MFR) assessment with cardiac positron emission computed tomography (PET/CT) is well established, and quantification relies on commercial software packages. However, for reliable use, repeatability and reproducibility are important. The aim of this study was therefore to investigate and compare between scans and software packages the repeatability and reproducibility of Rb-PET/CT estimated MFR.
Forty healthy volunteers completed two Rb-PET/CT rest and adenosine stress scans. syngo.MBF (Siemens), quantitative-gated SPECT (QGS) (Cedars-Sinai), and Corridor4DM (4DM) were used for analyses. Motion correction was available for 4DM. Fifty percent were men and age was 24 ± 4 years (mean ± SD). Repeatability of MFR varied between scans. syngo.MBF: mean difference (95% CI) 0.26 (- 0.03 to 0.54), P = 0.07, limits of agreement (LoA): - 1.43 to 1.95; QGS: 0.19 (- 0.08 to 0.46), P = 0.15, LoA: - 1.38 to 1.76; 4DM: 0.08 (- 0.17 to 0.34), P = 0.50, LoA: - 1.37 to 1.53; and 4DM motion corrected: 0.17 (- 0.17 to 0.51), P = 0.32, LoA: - 1.89 to 2.22. MFR was higher using 4DM +/- motion correction compared with syngo.MBF and QGS (all P < 0.0001). Concordance between syngo.MBF and QGS was high (P = 0.83).
Reproducibility of MFR varied for the different software. The highest concordance between MFRs was found between syngo.MBF and QGS.
利用心脏正电子发射计算机断层扫描（PET/CT）评估心肌血流储备（MFR）已得到广泛应用，其定量分析依赖于商业软件包。然而，为确保可靠使用，重复性和再现性至关重要。因此，本研究旨在调查和比较不同扫描及软件包之间，利用铷（Rb）-PET/CT估计MFR的重复性和再现性。
40名健康志愿者完成了两次Rb-PET/CT静息及腺苷负荷扫描。分析采用了syngo.MBF（西门子）、定量门控单光子发射计算机断层扫描（QGS）（雪松西奈医疗中心）和Corridor4DM（4DM）软件。4DM软件具备运动校正功能。受试者中50%为男性，年龄为24±4岁（均值±标准差）。不同扫描之间MFR的重复性存在差异。syngo.MBF：平均差异（95%置信区间）0.26（-0.03至0.54），P = 0.07，一致性界限（LoA）：-1.43至1.95；QGS：0.19（-0.08至0.46），P = 0.15，LoA：-1.38至1.76；4DM：0.08（-0.17至0.34），P = 0.50，LoA：-1.37至1.53；4DM运动校正后：0.17（-0.17至0.51），P = 0.32，LoA：-1.89至2.22。与syngo.MBF和QGS相比，采用4DM±运动校正时MFR更高（所有P < 0.0001）。syngo.MBF与QGS之间的一致性较高（P = 0.83）。
不同软件的MFR再现性有所不同。syngo.MBF与QGS之间的MFR一致性最高。
