Ballke E H, Wiersbitzky S, König A, Jährig K
Department of Pediatrics, Ernst-Moritz-Arndt-University Greifswald, GDR.
Z Erkr Atmungsorgane. 1988;171(2):132-4.
In 49 children with chronic nonspecific respiratory diseases (CNSRD) of them 6 with Cystic Fibrosis (CF), 18 with extrinsic bronchial asthma and 25 children with relapsing or chronic bronchitis, the tmpd were measured in the tracheobronchial system (bronchoscopy under general anaesthesia). The tmpd differed statistically highly significant (p less than 0.001). In asthmatics with significant eosinophilia in the bronchial secretions of the main bronchus we found a tmpd of 26.2 (+/- 9.2) mV, in bronchitics of 18.7 (+/- 6.2) mV and in CF-children receiving routinely N-acetylcysteine 6.1 (+/- 1.8) mV. Since the local application of this drug produced an additional immediate decrease of the tmpd in CF-children this suggests that such drugs, the presence or absence of eosinophils in the secretions, the products of intermediate cell metabolism or the different pathogenic process could be responsible for the varying values of the tmpd in the respiratory tract.
在49名患有慢性非特异性呼吸道疾病（CNSRD）的儿童中，其中6名患有囊性纤维化（CF），18名患有外源性支气管哮喘，25名患有复发性或慢性支气管炎，在气管支气管系统中测量跨黏膜电位差（tmpd）（全身麻醉下进行支气管镜检查）。tmpd在统计学上有高度显著差异（p小于0.001）。在主支气管支气管分泌物中有显著嗜酸性粒细胞增多的哮喘患者中，我们发现tmpd为26.2（±9.2）mV，在支气管炎患者中为18.7（±6.2）mV，在常规接受N-乙酰半胱氨酸治疗的CF儿童中为6.1（±1.8）mV。由于在CF儿童中局部应用这种药物会使tmpd立即进一步降低，这表明此类药物、分泌物中嗜酸性粒细胞的有无、中间细胞代谢产物或不同的致病过程可能是呼吸道中tmpd值变化的原因。
