乳酸脱氢酶升高病毒增强自然杀伤细胞介导的对小鼠间皮瘤发生的免疫监视。
Lactate dehydrogenase-elevating virus enhances natural killer cell-mediated immunosurveillance of mouse mesothelioma development.
作者信息
Mandour Mohamed F, Soe Pyone Pyone, Uyttenhove Catherine, Van Snick Jacques, Marbaix Etienne, Coutelier Jean-Paul
机构信息
1Unit of Experimental Medicine, de Duve Institute, Université Catholique de Louvain, SSS/DDUV - ICP, Av. Hippocrate 75, bte B1.75.02, 1200 Brussels, Belgium.
2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
出版信息
Infect Agent Cancer. 2020 May 7;15:30. doi: 10.1186/s13027-020-00288-6. eCollection 2020.
BACKGROUND
Viral infections can reduce early cancer development through enhancement of cancer immunosurveillance. This study was performed to analyse this effect of viral infection in a mouse model of solid tumor.
METHODS
The experimental model used was the effect of BALB/c mouse infection by lactate dehydrogenase-elevating virus on AB1 mesothelioma cancer development.
RESULTS
Acute infection with lactate dehydrogenase-elevating virus strongly reduced in vivo early AB1 mesothelioma growth and death resulting from cancer development. This effect was not due to a direct cytolytic effect of the virus on AB1 cells, but to an in vivo activation of natural killer cells. Gamma-interferon production rather than cytotoxic activity against AB1 cells mediated this protective effect. This gamma-interferon production by natural killer cells was dependent on interleukin-12 production.
CONCLUSIONS
Together with other reported effects of infectious agents on cancer development, this observation may support the hypothesis that enhancement of innate immunosurveillance against tumors may result from infection with common infectious agents through modulation of the host immune microenvironment.
背景
病毒感染可通过增强癌症免疫监视来减少早期癌症的发生。本研究旨在分析病毒感染在实体瘤小鼠模型中的这种作用。
方法
所采用的实验模型是乳酸脱氢酶升高病毒感染BALB/c小鼠对AB1间皮瘤癌症发生的影响。
结果
乳酸脱氢酶升高病毒的急性感染显著降低了体内早期AB1间皮瘤的生长以及癌症发展导致的死亡。这种作用并非由于病毒对AB1细胞的直接细胞溶解作用，而是由于体内自然杀伤细胞的激活。γ-干扰素的产生而非对AB1细胞的细胞毒性活性介导了这种保护作用。自然杀伤细胞产生的这种γ-干扰素依赖于白细胞介素-12的产生。
结论
连同其他已报道的感染因子对癌症发展的作用，这一观察结果可能支持这样的假说，即针对肿瘤的先天性免疫监视增强可能是由于常见感染因子通过调节宿主免疫微环境而导致的感染所致。
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