van der Merwe Nicolaas J, Karayiorgou Maria, Ehlers René, Roos Johannes L
Department of Psychiatry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Department of Psychiatry, Columbia University, New York, United States.
S Afr J Psychiatr. 2020 Apr 20;26:1393. doi: 10.4102/sajpsychiatry.v26i0.1393. eCollection 2020.
Schizophrenia is a heterogeneous disorder with strong genetic vulnerability. Family history of schizophrenia has been considered in genetic studies under several models. genetic events seem to play a larger role in sporadic cases.
This study used the familial-sporadic distinction with the aim of identifying a more homogeneous phenotype to delineate the genetic and clinical complexity of schizophrenia.
The study was conducted at Weskoppies Hospital, Pretoria, South Africa.
The study included 384 participants with schizophrenia or schizoaffective disorder from the Afrikaner founder population in South Africa who are considered comparable to Caucasian patients from the United States. A comprehensive data capturing sheet was completed.
When schizophrenia and schizoaffective disorder diagnoses were considered jointly, we found no significant differences between the sporadic and the familial groups for age at disease onset, season of birth, comorbid diagnoses, clinical symptomatology, history of suicide or marital status. When the diagnoses were examined separately, however, the sporadic schizoaffective disorder, bipolar type, was found to have a significantly lower age at onset (mean 20.6 vs. 25.3 years).
The sporadic schizoaffective disorder, bipolar type, forms a more homogeneous subgroup for genetic studies.
精神分裂症是一种具有高度遗传易感性的异质性疾病。在多种模型下的基因研究中都考虑了精神分裂症的家族史。基因事件似乎在散发性病例中起更大作用。
本研究采用家族性-散发性区分方法，旨在识别出更具同质性的表型，以描绘精神分裂症的遗传和临床复杂性。
该研究在南非比勒陀利亚的韦斯科皮斯医院进行。
该研究纳入了384名来自南非阿非利卡人创始人群体的精神分裂症或分裂情感性障碍患者，这些患者被认为与美国的白种人患者具有可比性。完成了一份全面的数据采集表。
当将精神分裂症和分裂情感性障碍诊断合并考虑时，我们发现散发性和家族性组在发病年龄、出生季节、共病诊断、临床症状、自杀史或婚姻状况方面没有显著差异。然而，当分别检查诊断时，发现散发性双相型分裂情感性障碍的发病年龄显著更低（平均20.6岁对25.3岁）。
散发性双相型分裂情感性障碍为基因研究形成了一个更具同质性的亚组。
