透明质酸酶辅助的大剂量皮下注射免疫球蛋白有效控制了一名患有严重T细胞淋巴细胞减少症的小儿心脏移植患者的细小病毒B19感染。
Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia.
作者信息
Cruz Rachel J, Dasso Joseph F, Duff Carla, Krasnopero Diane, Long Zsofia, Ellison Maryssa, Nieves Daime, Sriaroon Panida, Asante-Korang Alfred, Walter Jolan E
机构信息
Division of Allergy and Immunology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Department of Biology, University of Tampa, Tampa, Florida, USA.
出版信息
Open Forum Infect Dis. 2020 Mar 12;7(5):ofaa076. doi: 10.1093/ofid/ofaa076. eCollection 2020 May.
We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases.
我们用大剂量静脉注射免疫球蛋白（HD-IVIG）治疗了3例患有慢性细小病毒血症的小儿心脏移植患者。1例患有严重T细胞淋巴细胞减少症的患者出现了反复病毒血症和无菌性脑膜炎，当他改用大剂量透明质酸酶辅助皮下免疫球蛋白（HD-SCIG-Hy）时，症状明显缓解。我们讨论了HD-SCIG-Hy与HD-IVIG治疗类似病例的优势。
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