Chen Xu, Li Yang, Wang Jinxi, Cai Hongliu, Cao Hongcui, Sheng Jifang
Department of Obstetrics and Gynecology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Department of Critical Care Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):240-244. doi: 10.3785/j.issn.1008-9292.2020.03.08.
To analyze the clinical characteristics and pregnancy outcomes of pregnant women complicated with coronavirus disease 2019 (COVID-19).
The clinical data of 3 pregnant women with COVID-19 admitted to the First Affiliated Hospital of Zhejiang University School of Medicine from January 19 to February 10, 2020 were retrospectively analyzed.
There was one case in the first-trimester pregnancy (case 1), one in the second-trimester pregnancy (case 2) and one in third-trimester pregnancy (case 3). Cough, fever, fatigue, lung imaging changes were the main manifestations. The white cell count, lymphocyte percentage had no significantly changes in case 1 and case 3, while the levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), IL-6 and IL-10 elevated. The lymphocyte count and lymphocyte percentage decreased and the inflammatory indicators significantly increased in case 2. All patients were treated with antiviral, antitussive, oxygen inhalation; case 3 received glucocorticoids, case 2 with severe illness received glucocorticoids and additionally gamma globulin. All three cases were cured and discharged. Case 1 with early pregnancy chose to terminate pregnancy after discharge; case 2 chose to continue pregnancy without obstetric complications; and case 3 had cesarean section delivery due to abnormal fetal heart monitoring.
The report shows that COVID-19 in pregnancy women could be cured with active treatment, and the maternal and fetal outcomes can be satisfactory.
分析新型冠状病毒肺炎（COVID-19）合并妊娠妇女的临床特征及妊娠结局。
回顾性分析2020年1月19日至2月10日浙江大学医学院附属第一医院收治的3例COVID-19合并妊娠妇女的临床资料。
孕早期1例（病例1），孕中期1例（病例2），孕晚期1例（病例3）。主要表现为咳嗽、发热、乏力、肺部影像学改变。病例1和病例3白细胞计数、淋巴细胞百分比无明显变化，而C反应蛋白（CRP）、红细胞沉降率（ESR）、IL-6和IL-10水平升高。病例2淋巴细胞计数及淋巴细胞百分比下降，炎症指标明显升高。所有患者均接受抗病毒、止咳、吸氧治疗；病例3接受糖皮质激素治疗，病例2病情严重，接受糖皮质激素治疗并加用丙种球蛋白。3例均治愈出院。病例1孕早期出院后选择终止妊娠；病例2选择继续妊娠，无产科并发症；病例3因胎儿心率监测异常行剖宫产分娩。
报告显示，妊娠合并COVID-19经积极治疗可治愈，母婴结局良好。
