新蝶呤测定作为卵巢癌肿瘤标志物的意义。

The significance of neopterin determination as a tumour marker in ovarian cancer.

作者信息

Szarka G, Pulay T, Csömör S, Schumann B

机构信息

1st Department of Obstetrics and Gynaecology, Semmelweis University Medical School, Budapest, Hungary.

出版信息

Acta Chir Hung. 1988;29(4):359-64.

PMID:3239335

Abstract

The neopterin level of 164 urine samples of ovarian cancer patients was determined by high pressure liquid chromatography. Parallelly, the serum levels of CA 125, CEA and of lipid bound sialic acid were also determined. A good correlation was found both with CA 125 and with lipid-bound sialic acid. There was a closer correlation with the latter both in the patients showing remission and in the active tumour carriers. In patients with negative tumour markers (TM) in the sera examined, a tumour-free state was confirmed in 87.5% by neopterin determinations. Accordingly, authors recommend neopterin determination in patients who face a critical decision.

摘要

采用高压液相色谱法测定了164例卵巢癌患者尿液样本中的新蝶呤水平。同时，还测定了血清中CA 125、癌胚抗原（CEA）和脂质结合唾液酸的水平。发现新蝶呤水平与CA 125以及脂质结合唾液酸均具有良好的相关性。在病情缓解的患者和活跃肿瘤携带者中，新蝶呤水平与脂质结合唾液酸的相关性更为密切。在所检测血清中肿瘤标志物（TM）呈阴性的患者中，通过新蝶呤测定证实87.5%的患者处于无瘤状态。因此，作者建议在面临关键决策的患者中进行新蝶呤测定。