Department of Pharmacy, Kochi Medical School Hospital, Kohasu Kochi, Japan; Department of Biomedical Science, Kochi Medical Graduate School, Kohasu Kochi, Japan;, Email:
Department of Pharmacy, Kochi Medical School Hospital, Kohasu Kochi, Japan; Department of Biomedical Science, Kochi Medical Graduate School, Kohasu Kochi, Japan.
Pharmazie. 2020 May 1;75(5):191-194. doi: 10.1691/ph.2020.9950.
Juzentaihoto is a herbal medicine with reported anti-inflammatory effects, and it is predicted to improve inflammation and insulin sensitivity within obesity. In the present study, juzentaihoto hot water extract (JTT) was administered to obese type 2 diabetic model mice (KKAy) for 56 days. In addition, the effects of JTT on the adipose tissue, glucose metabolism, and blood lipids were evaluated for examining its impact on insulin sensitivity and obesity. As a result of JTT administration, KKAy mice exhibited suppressed adipocyte hypertrophy, decreased the mRNA levels of tumor necrosis factor α, and increased the mRNA levels of adiponectin in epididymal fat tissue. In addition, fasting blood glucose levels, blood triglyceride, and total cholesterol decreased. In summary, these data indicated that JTT administration suppressed the production of inflammatory cytokines and increased adiponectin levels in the adipose tissue. Therefore, with improved insulin sensitivity, blood glucose, and lipid decreased.
救心丹是一种具有抗炎作用的草药，据预测可改善肥胖症中的炎症和胰岛素敏感性。在本研究中，救心丹热水提取物（JTT）在 56 天内施用于肥胖 2 型糖尿病模型小鼠（KKAy）。此外，还评估了 JTT 对脂肪组织、葡萄糖代谢和血脂的影响，以检查其对胰岛素敏感性和肥胖的影响。JTT 给药后，KKAy 小鼠表现出脂肪细胞肥大受抑制，肿瘤坏死因子 α 的 mRNA 水平降低，以及附睾脂肪组织中脂联素的 mRNA 水平升高。此外，空腹血糖水平、血液甘油三酯和总胆固醇降低。总之，这些数据表明 JTT 给药可抑制脂肪组织中炎症细胞因子的产生并增加脂联素水平。因此，胰岛素敏感性提高，血糖和血脂降低。
