Gorini Francesca, Bustaffa Elisa, Bolignano Davide, Cori Liliana, Faita Francesco, Gastaldelli Amalia, Interdonato Monica, Minichilli Fabizio, Quattrone Giancarlo, Squadrito Francesco, Tripepi Giovanni, Vassalle Cristina, Bianchi Fabrizio
National Research Council, Institute of Clinical Physiology, Pisa, Italy
National Research Council, Institute of Clinical Physiology, Pisa, Italy.
BMJ Open. 2020 May 10;10(5):e036160. doi: 10.1136/bmjopen-2019-036160.
Environmental pollution has been progressively becoming one of the main risk factors to human diseases. In particular, populations living in high-contaminated sites are particularly exposed to environmental toxicants, with consequent increased risks to human health. In Italy, there are currently ongoing three epidemiological etiological studies aimed at evaluating the association between exposure to inorganic and organic chemicals and presence of biological markers of early effects in population living in three National Priority Contaminated Sites (NPCSs). Specifically, the correlations concern preclinical indicators of liver disease in Priolo NPCS, thyroid diseases in Milazzo-Valle del Mela NPCS and cardiovascular risk and kidney damage in Crotone NPCS.
Overall, approximately 1300 subjects of both sexes will be enrolled in the three NPCSs according to specific inclusion criteria. For each subject, serum and urine specimens are collected, on which the determination of biological markers of exposure and early effects for the selected outcomes are performed. Individual information on environmental and occupational exposure, medical history, diet and life habits is obtained through questionnaires provided by web platform. In Milazzo-Valle del Mela and Crotone NPCSs, not invasive instrumental and imaging examinations are performed in order to evaluate further risk factors of thyroid carcinoma and cardiovascular disease, respectively.
The protocol studies have been approved by the Ethics Committees responsible for the three involved NPCSs: the Ethics Committee 'Catania 2' for the NPCS of Priolo (21 July 2017, n. 500/2017/CECT2), the Ethics Committee of the University Hospitals of Messina for the NPCS of Milazzo-Valle del Mela (19 February 2018, n.2/2018); the Ethics Committee of the Region of Calabria for the NPCS of Crotone (20 July 2017, n. 174). Results will be disseminated among policy-makers, citizens, stakeholders and scientific community through the organisation of conferences and events, and the publication on international peer/reviewed journals.
环境污染已逐渐成为人类疾病的主要风险因素之一。特别是，生活在高污染地区的人群尤其容易接触环境毒物，从而增加了对人类健康的风险。在意大利，目前正在进行三项流行病学病因学研究，旨在评估接触无机和有机化学物质与生活在三个国家重点污染场地（NPCS）的人群中早期效应生物标志物的存在之间的关联。具体而言，这些相关性涉及普里奥洛NPCS中肝病的临床前指标、米拉佐-梅拉谷NPCS中的甲状腺疾病以及克罗托内NPCS中的心血管风险和肾脏损害。
总体而言，将根据特定纳入标准在三个NPCS中招募约1300名男女受试者。对于每个受试者，收集血清和尿液样本，并对其进行所选结局的接触和早期效应生物标志物的测定。通过网络平台提供的问卷获取有关环境和职业接触、病史、饮食和生活习惯的个人信息。在米拉佐-梅拉谷和克罗托内NPCS中，分别进行非侵入性仪器检查和成像检查，以评估甲状腺癌和心血管疾病的进一步风险因素。
该方案研究已获得负责三个相关NPCS的伦理委员会批准：普里奥洛NPCS的“卡塔尼亚2”伦理委员会（2017年7月21日，第500/2017/CECT2号）、米拉佐-梅拉谷NPCS的墨西拿大学医院伦理委员会（2018年2月19日，第2/2018号）；科森扎地区伦理委员会对克罗托内NPCS的批准（2017年7月20日，第174号）。研究结果将通过组织会议和活动以及在国际同行评审期刊上发表，在政策制定者、公民、利益相关者和科学界中进行传播。
