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WBP2 致癌基因在人类癌症中的新兴作用。

The emerging roles of WBP2 oncogene in human cancers.

机构信息

Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.

出版信息

Oncogene. 2020 Jun;39(24):4621-4635. doi: 10.1038/s41388-020-1318-0. Epub 2020 May 11.

DOI:10.1038/s41388-020-1318-0
PMID:32393834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7286818/
Abstract

WW domain-binding protein 2 (WBP2) is an emerging oncoprotein. Over the past decade, WBP2 surfaced as a key node connecting key signaling pathways associated with ER/PR, EGFR, PIK, Hippo, and Wnt in cancer. In addition to the oncogenic functions of WBP2, this review discusses the latest research regarding the multilevel regulation and modes of action of WBP2 and how they can be exploited for molecular medicine. In translational research, evidence supports the role of WBP2 as a biomarker for early detection, prognosis, and companion diagnostics in breast cancer. Finally, we envision new trends in WBP2 research in the space of molecular etiology of cancer, targeted therapeutics, and precision medicine.

摘要

WW 结构域结合蛋白 2（WBP2）是一种新兴的癌蛋白。在过去的十年中，WBP2 作为一个关键节点出现在与癌症相关的 ER/PR、EGFR、PIK、Hippo 和 Wnt 等关键信号通路中。除了 WBP2 的致癌功能外，本综述还讨论了 WBP2 的多层次调控及其作用模式的最新研究，以及如何将其应用于分子医学。在转化研究中，有证据表明 WBP2 可作为乳腺癌早期检测、预后和伴随诊断的生物标志物。最后，我们设想在癌症的分子病因学、靶向治疗和精准医学领域，WBP2 研究的新趋势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/7286818/bb10dd51cc47/41388_2020_1318_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/7286818/bb10dd51cc47/41388_2020_1318_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/7286818/8bc23a6cb294/41388_2020_1318_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/7286818/f49bc5d9a54a/41388_2020_1318_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/7286818/4d14dcfeb0e1/41388_2020_1318_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/7286818/97e32cde6674/41388_2020_1318_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/7286818/23080aec43f0/41388_2020_1318_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/7286818/a3a63f12946d/41388_2020_1318_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cc0/7286818/bb10dd51cc47/41388_2020_1318_Fig7_HTML.jpg

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