Dücker P, Hüning S, Rohde S, Lorenzen J, Nashan D
Klinik für Dermatologie, Klinikum Dortmund, Beurhausstr. 40, 44137, Dortmund, Deutschland.
Institut für Radiologie und Neuroradiologie, Klinikum Dortmund, 44137, Dortmund, Deutschland.
Hautarzt. 2020 Jul;71(7):553-556. doi: 10.1007/s00105-020-04599-y.
We report the case of an 85-year-old chronic lymphocytic leukemia patient with a local metastatic MCVPyV-negative Merkel cell carcinoma at initial diagnosis. Therapy comprised surgical excision and radiotherapy but without lymphadenectomy. Six months after the primary diagnosis, liver metastases were detected. They responded to the PD-L1 inhibitor avelumab for more than 15 months. Thus, we postulate a synergistic effect of combined therapy with chlorambucil and avelumab through a mutual improvement of immune function, from which both diseases benefit.
我们报告了一例85岁的慢性淋巴细胞白血病患者，初诊时患有局部转移性MCVPyV阴性默克尔细胞癌。治疗包括手术切除和放疗，但未进行淋巴结清扫术。初次诊断后6个月，检测到肝转移。肝转移灶对程序性死亡受体配体1（PD-L1）抑制剂阿维鲁单抗反应超过15个月。因此，我们推测苯丁酸氮芥与阿维鲁单抗联合治疗通过共同改善免疫功能产生协同效应，两种疾病均从中获益。
