Li Chaoran, Li Lu, Wu Xiuhua, Shi Jing, Liu Jinjing, Zhou Jiaxin, Wang Li, Tian Xinping, Zeng Xiaofeng, Zheng Wenjie
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, 100730, China.
Clin Rheumatol. 2020 Nov;39(11):3449-3454. doi: 10.1007/s10067-020-05026-2. Epub 2020 May 11.
To investigate the clinical characteristics of Bechet's disease (BD) with respect to gender and age in China.
Clinical data of 489 BD patients admitted to Peking Union Medical College Hospital (PUMCH) and registered by the BD registry database established by PUMCH from March 2014 to January 2019 were collected and analyzed in this study. Demographics, medical histories, clinical manifestations, laboratory test results, imaging findings, assessment of disease activity, treatment regimen, as well as the outcomes were reviewed.
A total of 489 BD patients were included in this study, among them 286 males (58.5%) and 203 females (41.5%) with a male-to-female ratio of 1.41 and a median age of 34 years (interquartile range 28-44 years old). The results revealed that ocular lesions (P = 0.005), vascular lesions(P < 0.001), pseudofolliculitis (P < 0.001), and positive pathergy test (P = 0.002) were more commonly found in males, while genital ulceration was more prevalent in females (P < 0.001). Vascular lesions (P = 0.024) and gastrointestinal ulcers (P = 0.010) were more common in BD patients after the age of 40, while pseudofolliculitis was more common in patients under the age of 40 (P = 0.004) and ocular lesions (P = 0.017) occurred mainly in patients under the age of 35. Male predominance of ocular involvement was more apparent in their third decades (P< 0.006), while vascular lesions were prominently presented in male patients at the age of 30-40 (P= 0.006). Female predominance of genital ulcers was observed in patients at the age of 30-40 (P< 0.006).
The clinical characteristics of BD were different with respect to gender and age. Key Points • Ocular and vascular lesions, pseudofolliculitis, and positive pathergy test were more common in male BD patients. • Genital ulceration showed female predominance in BD patients. • Vascular lesions and gastrointestinal ulcers were more common in older BD patients. • Pseudofolliculitis and ocular lesions occurred mainly in younger BD patients.
探讨中国白塞病（BD）在性别和年龄方面的临床特征。
本研究收集并分析了2014年3月至2019年1月期间在北京协和医院（PUMCH）住院并纳入PUMCH建立的BD注册数据库的489例BD患者的临床资料。回顾了人口统计学、病史、临床表现、实验室检查结果、影像学表现、疾病活动度评估、治疗方案以及治疗结果。
本研究共纳入489例BD患者，其中男性286例（58.5%），女性203例（41.5%），男女比例为1.41，中位年龄为34岁（四分位间距为28 - 44岁）。结果显示，眼部病变（P = 0.005）、血管病变（P < 0.001）、假性毛囊炎（P < 0.001）和针刺试验阳性（P = 0.002）在男性中更常见，而生殖器溃疡在女性中更为普遍（P < 0.001）。血管病变（P = 0.024）和胃肠道溃疡（P = 0.010）在40岁以上的BD患者中更常见，而假性毛囊炎在40岁以下的患者中更常见（P = 0.004），眼部病变（P = 0.017）主要发生在35岁以下的患者中。眼部受累的男性优势在第三个十年更为明显（P < 0.006），而血管病变在30 - 40岁的男性患者中更为突出（P = 0.006）。生殖器溃疡的女性优势在30 - 40岁的患者中观察到（P < 0.006）。
BD的临床特征在性别和年龄方面存在差异。要点 • 眼部和血管病变、假性毛囊炎和针刺试验阳性在男性BD患者中更常见。 • 生殖器溃疡在BD患者中以女性为主。 • 血管病变和胃肠道溃疡在老年BD患者中更常见。 • 假性毛囊炎和眼部病变主要发生在年轻的BD患者中。
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