Kim Ji Na, Kwak Sang Gyu, Choe Jung-Yoon, Kim Seong-Kyu
Division of Rheumatology, Department of Internal Medicine, Arthritis and Autoimmunity Research Centre, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
Department of Medical Statistics, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
Clin Exp Rheumatol. 2017 Nov-Dec;35 Suppl 108(6):38-42. Epub 2017 Jan 30.
The aim of this study is to identify the prevalence of Behçet's disease (BD) from data in the Healthcare Bigdata Hub of the Health Insurance Review & Assessment (HIRA) Service from 2011 to 2015 in Korea.
This study collected information on primary and auxiliary diagnoses of BD (M352) by physicians according to the Korean Standard Classification of Diseases (KCD) codes. The prevalence of BD was assessed on the basis of age, sex, and geographical distribution. We used time series analysis, using the ARIMA model for the expected prevalence of BD from 2016 to 2025.
The overall prevalence of BD was gradually increased, ranging from 32.8 to 35.7 per 100,000 population over the study period. The male to female ratio of BD ranged from 0.54:1 to 0.56:1, revealing a female predominance from 2011 to 2015. Among five districts in Korea, the prevalence in the Seoul Metropolitan district was the highest, with a slowly increasing trend for the study period, accounting for about 60.3% of total BD patients. The expected prevalence of BD patients was estimated to range from 36.9 (95% CI 35.0 - 39.0) to 44.7 (95% CI 40.2 - 49.6) between 2016 and 2025.
This study found that the overall prevalence of BD is estimated to be approximately 35.0 per 100,000 population, with female predominance, and predicts gradually increased prevalence of BD in Korea.
本研究旨在根据2011年至2015年韩国健康保险审查与评估（HIRA）服务的医疗大数据中心的数据，确定白塞病（BD）的患病率。
本研究根据韩国疾病标准分类（KCD）代码收集医生对白塞病（M352）的主要和辅助诊断信息。基于年龄、性别和地理分布对白塞病的患病率进行评估。我们使用时间序列分析，采用自回归积分移动平均（ARIMA）模型预测2016年至2025年白塞病的预期患病率。
在研究期间，白塞病的总体患病率逐渐上升，每10万人口中患病率从32.8上升至35.7。白塞病的男女比例在0.54:1至0.56:1之间，表明2011年至2015年女性占主导地位。在韩国的五个地区中，首尔大都市区的患病率最高，在研究期间呈缓慢上升趋势，约占白塞病患者总数的60.3%。预计2016年至2025年白塞病患者的预期患病率在36.9（95%可信区间35.0 - 39.0）至44.7（95%可信区间40.2 - 49.6）之间。
本研究发现，白塞病的总体患病率估计约为每10万人口35.0例，并以女性为主，预计韩国白塞病的患病率将逐渐上升。
