Faculty of Kinesiology and Physical Education, University of Toronto, 55 Harbord Street, Toronto, ON, M5S 2W6, Canada.
Faculty of Kinesiology, Sport, and Recreation, University of Alberta, 113 University Hall, Edmonton, AB, T6G 2H9, Canada.
Cancer Causes Control. 2020 Jul;31(7):669-681. doi: 10.1007/s10552-020-01308-x. Epub 2020 May 11.
Kidney cancer survivors spend large quantities of time sedentary and little time physically active, which negatively impacts quality of life (QoL). This study examined (1) the association of reallocating sedentary time to sleep, light physical activity (PA), or moderate-to-vigorous PA (MVPA) on QoL in kidney cancer survivors and (2) the threshold at which results are clinically meaningful.
Kidney cancer survivors (N = 463) completed a survey including the Godin Leisure-Time Exercise Questionnaire, sitting time, sleep duration, and Functional Assessment of Cancer Therapy (FACT) scales. Isotemporal substitution analyses estimated associations of reallocating sedentary time to PA and sleep on QoL.
Reallocating 10 min/day of sedentary time to MVPA was significantly associated with higher scores on the Trial Outcome Index-Fatigue (B = 0.60, SE = 0.25, p = 0.02), FACT-Fatigue (B = 0.71, SE = 0.32, p = 0.03), functional well-being (B = 0.18, SE = 0.08, p = 0.02), and fatigue subscales (B = 0.35, SE = 0.15, p = 0.02). Reallocating sedentary time to sleep was significantly associated with higher FACT-General (B = 0.15, SE = 0.08, p = 0.04) and functional well-being subscale (B = 0.06, SE = 0.03, p = 0.049) scores. Reallocating sedentary time to light PA was significantly associated with higher fatigue subscale scores (B = 0.46, SE = 0.23, p = 0.045). Kidney cancer survivors would need to reallocate a minimum of about 83, 200, and 65 min/day of MVPA, sleep, and light PA, respectively, for associations to be clinically meaningful.
Reallocating sedentary time to MVPA, light PA, or sleep at higher doses is associated with better fatigue and physical aspects of QoL. Interventions should consider replacing sedentary time with MVPA or light PA in a gradual manner, and improve sleep quality for kidney cancer survivors.
肾癌幸存者久坐时间长，身体活动时间短，这对生活质量（QoL）有负面影响。本研究考察了（1）将久坐时间重新分配到睡眠、轻度体力活动（PA）或中等到剧烈体力活动（MVPA）对肾癌幸存者 QoL 的影响，以及（2）结果具有临床意义的阈值。
463 例肾癌幸存者完成了一项调查，包括戈丁休闲时间运动问卷、久坐时间、睡眠时间和癌症治疗功能评估（FACT）量表。等时替代分析估计了将久坐时间重新分配到 PA 和睡眠对 QoL 的影响。
每天将 10 分钟的久坐时间重新分配到 MVPA 与更高的试验结局指数疲劳评分（B=0.60，SE=0.25，p=0.02）、FACT-疲劳评分（B=0.71，SE=0.32，p=0.03）、功能健康评分（B=0.18，SE=0.08，p=0.02）和疲劳子量表评分（B=0.35，SE=0.15，p=0.02）显著相关。将久坐时间重新分配到睡眠与更高的 FACT-一般评分（B=0.15，SE=0.08，p=0.04）和功能健康评分子量表（B=0.06，SE=0.03，p=0.049）显著相关。将久坐时间重新分配到轻度 PA 与更高的疲劳子量表评分显著相关（B=0.46，SE=0.23，p=0.045）。肾癌幸存者需要每天重新分配至少 83、200 和 65 分钟的 MVPA、睡眠和轻度 PA，才能达到有临床意义的关联。
更高剂量的将久坐时间重新分配到 MVPA、轻度 PA 或睡眠与更好的疲劳和生活质量的身体方面相关。干预措施应考虑逐渐用 MVPA 或轻度 PA 替代久坐时间，并改善肾癌幸存者的睡眠质量。
