Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska.
Psychooncology. 2019 Jul;28(7):1430-1437. doi: 10.1002/pon.5091. Epub 2019 May 8.
Physical activity is associated with better quality of life (QOL) among breast cancer survivors. However, it is unknown the extent to which time spent sedentary or replacing this time with active behaviors may affect QOL. Our aim was to determine the effect of substituting time between sedentary and active behaviors on QOL indicators in breast cancer survivors.
An isotemporal substitution approach was used to examine the associations of reallocating time to sedentary and active behaviors measured by accelerometry with Functional Assessment of Cancer Treatment-Breast (FACT-B; total, physical, social, emotional, functional well-being, and breast cancer-specific concerns) and the Hospital Anxiety and Depression Scale (HADS) scores in a pooled analysis of breast cancer survivors (n = 753; M = 56.9 ± 9.5 y) from two observational studies.
Reallocating 30 minutes of sedentary time to 30 minutes of moderate-to-vigorous intensity physical activity (MVPA) was associated with improved FACT-B total (B = 3.0; 95% CI, 0.6-4.5), physical well-being (B = 0.8; 95% CI, 0.33-1.2), and functional well-being (B = 0.6; 95% CI, 0.03-1.2) scores. Reallocating 30 minutes of light activity to 30 minutes of MVPA was associated with improved FACT-B total (B = 2.4; 95% CI, 0.3-6.0) and physical well-being (B = 0.72; 95% CI, 0.27-1.2) scores. There was no significant substitution of time effects on HADS scores.
Substituting sedentary time with MVPA showed the greatest range of effects across QOL indicators. These results can inform intervention development interventions and more comprehensive activity recommendations for breast cancer survivors.
身体活动与乳腺癌幸存者的生活质量（QOL）改善有关。然而，目前尚不清楚花费在久坐不动的时间以及用积极行为代替这段时间会对 QOL 产生何种影响。我们的目的是确定在乳腺癌幸存者中，用积极行为替代久坐不动的时间对 QOL 指标的影响程度。
采用等时替代方法，考察了使用加速度计测量的久坐和积极行为之间的时间分配变化与癌症治疗功能评估-乳房（FACT-B；总评分、生理、社会、情感、功能健康状况和乳腺癌特定问题）和医院焦虑抑郁量表（HADS）评分之间的关联。对两项观察性研究中的 753 名乳腺癌幸存者（M=56.9±9.5 岁）进行了汇总分析。
将 30 分钟的久坐时间重新分配为 30 分钟的中等到剧烈强度的身体活动（MVPA）与 FACT-B 总分（B=3.0；95%置信区间，0.6-4.5）、生理健康状况（B=0.8；95%置信区间，0.33-1.2）和功能健康状况（B=0.6；95%置信区间，0.03-1.2）的提高有关。将 30 分钟的低强度活动重新分配为 30 分钟的 MVPA 与 FACT-B 总分（B=2.4；95%置信区间，0.3-6.0）和生理健康状况（B=0.72；95%置信区间，0.27-1.2）的提高有关。HADS 评分没有显著的时间替代效应。
用 MVPA 替代久坐时间对 QOL 指标的影响范围最广。这些结果可以为乳腺癌幸存者的干预措施制定和更全面的活动推荐提供信息。
