Frase Lukas, Jahn Friederike, Tsodor Sulamith, Krone Lukas, Selhausen Peter, Feige Bernd, Maier Jonathan G, Piosczyk Hannah, Riemann Dieter, Nitsche Michael A, Nissen Christoph
Department of Psychiatry and Psychotherapy, Medical Center, University of Freiburg, Freiburg, Germany.
Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Neuromodulation. 2021 Jul;24(5):910-915. doi: 10.1111/ner.13163. Epub 2020 May 11.
A proposed replay of memory traces between the hippocampus and frontal cortical brain areas during sleep is of high relevance for overnight memory consolidation. Recently, we demonstrated that bi-frontal anodal transcranial direct current stimulation (tDCS) prior to sleep increases waking EEG gamma power and decreases total sleep time during the night. It is unclear whether this effect on cortical excitability has an influence on overnight memory consolidation. We hypothesized that bi-frontal evening tDCS interferes with overnight memory consolidation with a polarity specific impairment following anodal tDCS.
Nineteen healthy participants underwent a within-subject, repeated-measures protocol in the sleep laboratory with bi-frontal tDCS applied prior to sleep according to the experimental protocol (anodal, cathodal, sham stimulation). Memory tasks for declarative and procedural memory were assessed prior to tDCS and on the following morning.
No deterioration of overnight memory consolidation following evening offline bi-frontal tDCS could be detected.
CONCLUSION(S): The application of tDCS can be considered safe regarding overnight memory consolidation and represents a promising treatment approach in conditions of decreased vigilance and arousal.
睡眠期间海马体与额叶皮质脑区之间记忆痕迹的拟议重演与夜间记忆巩固高度相关。最近，我们证明睡眠前进行双额叶阳极性经颅直流电刺激（tDCS）会增加清醒时脑电图的伽马波功率，并减少夜间总睡眠时间。目前尚不清楚这种对皮质兴奋性的影响是否会对夜间记忆巩固产生影响。我们假设，双额叶晚间tDCS会干扰夜间记忆巩固，阳极tDCS后会出现极性特异性损伤。
19名健康参与者在睡眠实验室接受了一项受试者内重复测量方案，根据实验方案（阳极、阴极、假刺激）在睡眠前进行双额叶tDCS。在tDCS之前和第二天早晨评估陈述性和程序性记忆的记忆任务。
未检测到晚间离线双额叶tDCS后夜间记忆巩固能力下降。
就夜间记忆巩固而言，tDCS的应用可被视为安全的，并且在警觉性和觉醒降低的情况下是一种有前景的治疗方法。
