Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Nov;12(6):e1643. doi: 10.1002/wnan.1643. Epub 2020 May 11.
Nanomaterials-based prodrug activation systems have been widely explored in cancer therapy, aiming at overcoming limited dosage formulation, systemic toxicity, and insufficient pharmacokinetic performance of parent drugs. For better delivery control, various stimuli systems, especially nanomaterials-based ones, have come to the forefront. Among them, near-infrared (NIR) light takes advantage of on-demand/site-specific regulation and non-invasiveness. In this review, we will address the developments of nanomaterials-based prodrug over the last decade, the activation mechanisms, and bioapplications under NIR light triggering. The advantages and limitations of NIR-triggered prodrug activation strategies and the perspectives of the next-generation prodrug nanomedicine will also be summarized. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.
基于纳米材料的前药激活系统在癌症治疗中得到了广泛的探索，旨在克服母体药物的有限剂量配方、全身毒性和不足的药代动力学性能。为了更好地控制输送，各种刺激系统，特别是基于纳米材料的刺激系统，已经成为研究的重点。其中，近红外（NIR）光利用了按需/定点调节和非侵入性。在这篇综述中，我们将讨论过去十年中基于纳米材料的前药的发展、在近红外光触发下的激活机制和生物应用。我们还将总结 NIR 触发前药激活策略的优缺点以及下一代前药纳米医学的展望。本文属于以下分类：治疗方法和药物发现 > 用于肿瘤疾病的纳米医学治疗方法和药物发现 > 新兴技术。
