Department of Nephrology, Antalya Atatürk State Hospital, Antalya, Turkey.
Department of Nephrology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
Saudi J Kidney Dis Transpl. 2020 Mar-Apr;31(2):537-541. doi: 10.4103/1319-2442.284033.
Familial Mediterranean fever (FMF) is an autosomal recessive disease charac-terized by recurrent fever episodes and polyserositis. The most important complication is amyloidosis. Nonamyloidotic nephropathy in FMF is poorly documented. Besides amyloidosis, different types of glomerulonephritis may rarely be seen in FMF patients. A 24-year-old male patient followed up due to FMF was evaluated for macroscopic hematuria and acute kidney injury. The patient was diagnosed as immunoglobulin A nephropathy with renal biopsy. The patient gave a good response to colchicine and steroid treatment. The case reports in the literature about the treatment of the patients with association of FMF and glomerulonephritis are insufficient, and there are no satisfactory epidemiological and treatment outcome reports.
家族性地中海热（FMF）是一种常染色体隐性疾病，其特征是反复发作的发热和多浆膜炎。最主要的并发症是淀粉样变性。FMF 中的非淀粉样变性肾病记录较少。除淀粉样变性外，FMF 患者中也可能偶尔会出现不同类型的肾小球肾炎。一名 24 岁男性因 FMF 就诊，因肉眼血尿和急性肾损伤进行评估。患者经肾活检诊断为免疫球蛋白 A 肾病。患者对秋水仙碱和类固醇治疗反应良好。关于 FMF 与肾小球肾炎相关患者的治疗，文献中的病例报告不足，也没有令人满意的流行病学和治疗结果报告。
