Nagasawa Hiroki, Omori Kazuhiko, Takeuchi Ikuto, Yanagawa Youichi
Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, Shizuoka, Japan.
J Emerg Trauma Shock. 2020 Jan-Mar;13(1):45-49. doi: 10.4103/JETS.JETS_105_19. Epub 2020 Mar 19.
Few reports have investigated the time course of fibrinogen (or fibrin) degradation product (FDP) levels for trauma patients in the subacute phase.
This study aimed to investigate the time course of the FDP levels among patients with moderate and severe trauma in the subacute phase.
A retrospective medical chart review in a single hospital.
From September 2017 to March 2018, a medical chart review was retrospectively performed for all patients with trauma who were admitted to our department, and these patients were included as participants in the present study. We collected the data on each patient's sex, age, presence of head injury, mechanism of injury, Glasgow Coma Scale on arrival, systolic blood pressure, heart rate, type of injury (blunt versus penetrating), injury severity score, complication of infection, surgical procedure, duration of admission, survival rate, and FDP level from the 1 to 7 hospital day. The average level of FDP on each hospital day was compared with that on the previous day.
The statistical analyses were performed using a paired Student's -test. < 0.05 was considered to indicate a statistically significant difference.
From the 1 to 4 hospital day, the average level of FDP significantly diminished day by day. However, from the 5 hospital day, the average level significantly increased. This trend persisted even after excluding the complications of infection and surgical procedures performed between the 2 and 7 hospital day.
Among trauma patients, the average level of FDP significantly diminished day by day from the admission to the 4 hospital day; however, from the 5 hospital day, the average level significantly increased. Further studies are needed to determine the time course of FDP or D-dimer levels in the long term and when FDP levels return to normal limits.
很少有报告研究创伤患者亚急性期纤维蛋白原（或纤维蛋白）降解产物（FDP）水平的时间进程。
本研究旨在调查中重度创伤患者亚急性期FDP水平的时间进程。
在一家医院进行回顾性病历审查。
2017年9月至2018年3月，对我院收治的所有创伤患者进行回顾性病历审查，这些患者被纳入本研究。我们收集了每位患者的性别、年龄、头部损伤情况、损伤机制、入院时的格拉斯哥昏迷量表评分、收缩压、心率、损伤类型（钝器伤与穿透伤）、损伤严重程度评分、感染并发症、手术操作、住院时间、生存率以及第1至7个住院日的FDP水平数据。比较每个住院日FDP的平均水平与前一天的水平。
采用配对t检验进行统计分析。P<0.05被认为具有统计学显著差异。
从第1至4个住院日，FDP的平均水平逐日显著下降。然而，从第5个住院日开始，平均水平显著上升。即使排除第2至7个住院日期间的感染并发症和手术操作，这一趋势仍然存在。
在创伤患者中，从入院到第4个住院日，FDP的平均水平逐日显著下降；然而，从第5个住院日开始，平均水平显著上升。需要进一步研究来确定FDP或D - 二聚体水平的长期时间进程以及FDP水平何时恢复到正常范围。
