Ghoneum Alia, Abdulfattah Ammar Yasser, Said Neveen
Department of Cancer Biology, Wake Forest University School of Medicine, and Comprehensive Cancer Center, Winston Salem, NC 27157, USA.
Department of Pathology, Wake Forest University School of Medicine, and Comprehensive Cancer Center, Winston Salem, NC 27157, USA.
J Cell Immunol. 2020;2(2):68-73. doi: 10.33696/immunology.1.022.
Ovarian cancer stands as the most lethal gynecologic malignancy and remains the fifth most common gynecologic cancer. Poor prognosis and low five-year survival rate are attributed to nonspecific symptoms at early phases along with a lack of effective treatment at advanced stages. It is thus paramount, that ovarian carcinoma be viewed through several lenses in order to gain a thorough comprehension of its molecular pathogenesis, epidemiology, histological subtypes, hereditary factors, diagnostic approaches, and methods of treatment. Above all, it is crucial to dissect the role that the unique peritoneal tumor microenvironment plays in ovarian cancer progression and metastasis. This short communication seeks to underscore several important aspects of the PI3K/AKT/mTOR/NFκB pathway in the context of ovarian cancer and discuss recent advances in targeting this pathway.
卵巢癌是最致命的妇科恶性肿瘤，也是第五大常见妇科癌症。预后不良和五年生存率低归因于早期阶段的非特异性症状以及晚期缺乏有效的治疗方法。因此，至关重要的是要从多个角度看待卵巢癌，以便全面了解其分子发病机制、流行病学、组织学亚型、遗传因素、诊断方法和治疗方法。最重要的是，剖析独特的腹膜肿瘤微环境在卵巢癌进展和转移中所起的作用至关重要。本简短通讯旨在强调PI3K/AKT/mTOR/NFκB通路在卵巢癌背景下的几个重要方面，并讨论靶向该通路的最新进展。
