Xu Lei, Wang Renjie, Liu Hongyu, Wang Jiaoqi, Liang Wenzhao, Mang Jing, Xu Zhongxin
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
Department Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, China.
J Ultrasound Med. 2020 Nov;39(11):2201-2209. doi: 10.1002/jum.15331. Epub 2020 May 12.
Our study aimed to evaluate the diagnostic performances of 3 routine examination methods for cerebrovascular disease in a rabbit carotid artery atherosclerosis model.
A total of 12 New Zealand rabbits were included: 4 in a control group and 8 in an experimental group. A clinically relevant atherosclerosis rabbit model was induced by left common carotid artery ligation and a 12-week high-fat diet. Atherosclerosis was further confirmed by a histopathologic analysis. Then carotid ultrasound (US) imaging, high-resolution magnetic resonance imaging (HRMRI), and positron emission tomography (PET)/computed tomography (CT) were performed on this model to evaluate the diagnostic performances.
Carotid US showed plaque formation in the left common carotid artery and little plaque in the right common carotid artery in the experimental group. In addition, HRMRI showed stenosis formation in the left common carotid artery in the experimental group. At the horizontal level, plaques were found in the left common carotid artery, and no plaques were found in the right common carotid artery in the experimental group. Also, PET/CT showed local hypermetabolism and vulnerable plaques in the left common carotid artery of the experimental group, whereas no hypermetabolism was found in the right common carotid artery of the experimental group. Moreover, the soft plaques detected by carotid US were different from the vulnerable plaques detected by PET/CT. The unstable plaques on HRMRI were the same as the hypermetabolic vulnerable plaques on PET/CT.
High-resolution MRI is recommended for the evaluation of neck and intracranial vascular stenosis and plaque properties in patients with stroke.
我们的研究旨在评估3种常规检查方法对兔颈动脉粥样硬化模型中脑血管疾病的诊断性能。
共纳入12只新西兰兔：对照组4只，实验组8只。通过左颈总动脉结扎和12周高脂饮食诱导建立具有临床相关性的动脉粥样硬化兔模型。通过组织病理学分析进一步证实动脉粥样硬化。然后对该模型进行颈动脉超声（US）成像、高分辨率磁共振成像（HRMRI）和正电子发射断层扫描（PET）/计算机断层扫描（CT），以评估诊断性能。
实验组中，颈动脉超声显示左颈总动脉有斑块形成，右颈总动脉几乎无斑块。此外，HRMRI显示实验组左颈总动脉有狭窄形成。在横断层面，实验组左颈总动脉发现有斑块，右颈总动脉未发现斑块。PET/CT显示实验组左颈总动脉有局部高代谢和易损斑块，而实验组右颈总动脉未发现高代谢。而且，颈动脉超声检测到的软斑块与PET/CT检测到的易损斑块不同。HRMRI上的不稳定斑块与PET/CT上的高代谢易损斑块相同。
对于评估中风患者的颈部和颅内血管狭窄及斑块性质，推荐使用高分辨率MRI。
