弥合差距：遗传背景对肿瘤发生途径的影响。

Bridging the Gap: The Impact of Genetic Ancestry on Routes to Tumorigenesis.

机构信息

Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA.

出版信息

Cancer Cell. 2020 May 11;37(5):619-621. doi: 10.1016/j.ccell.2020.04.011.

DOI:10.1016/j.ccell.2020.04.011

PMID:32396853

Abstract

Whether ancestry drives molecular differences that underlie disparities in cancer incidence and outcome is poorly understood. In this issue of Cancer Cell, Carrot-Zhang et al., through a rigorous analytical framework, explore ancestry-specific patterns of molecular alterations in cancers and demonstrate the need for novel strategies to address this formidable challenge.

摘要

遗传背景是否导致了癌症发病率和结局差异的分子基础尚不清楚。在本期《癌细胞》杂志中，Carrot-Zhang 等人通过严格的分析框架，探讨了癌症中遗传背景特异性的分子改变模式，并表明需要新的策略来应对这一艰巨的挑战。