Riikonen R, Santavuori P, Meretoja O, Sainio K, Neuvonen P J, Tokola R A
Children's Hospital, University of Helsinki, Finland.
Brain Dev. 1988;10(5):300-4. doi: 10.1016/s0387-7604(88)80060-3.
Five patients with infantile spasms and hypsarrhythmia and one with Lennox-Gastaut syndrome were treated with brief thiopentone anaesthesia as the primary treatment of infantile spasms. Thiopentone (30 mg/kg) was given intravenously and burst suppression was reached in EEG in three patients by this dose. The results were disappointing. In three patients a transient beneficial effect on spasms and hypsarrhythmia was seen, but all patients relapsed. Three other patients had anaesthesia for surgery. The spasms ceased and hypsarrhythmia disappeared dramatically, and the effect was permanent. The possible mechanisms of the therapeutic effect are discussed. It seems advisable to give anaesthesia and surgery prior to steroid treatment in any case where the both are needed.
五例患有婴儿痉挛症和高峰节律紊乱的患儿以及一例患有Lennox-Gastaut综合征的患儿接受了硫喷妥钠短暂麻醉，作为婴儿痉挛症的主要治疗方法。静脉注射硫喷妥钠（30毫克/千克），三名患者通过该剂量在脑电图中达到爆发抑制。结果令人失望。三名患者对痉挛和高峰节律紊乱出现短暂有益效果，但所有患者均复发。另外三名患者接受手术麻醉。痉挛停止，高峰节律紊乱显著消失，且效果持久。讨论了治疗效果的可能机制。在任何同时需要麻醉和手术的情况下，似乎建议在使用类固醇治疗之前先进行麻醉和手术。
