Mankad V N, Yang Y M, Williams J P, Brogdon B G
Comprehensive Sickle Cell Center, University of South Alabama College of Medicine, Mobile 36617.
Am J Pediatr Hematol Oncol. 1988 Winter;10(4):344-7. doi: 10.1097/00043426-198824000-00016.
Assessment of the bone marrow in sickle cell patients with or without pain crises can be accomplished using a variety of imaging techniques. Conventional radiography is the least sensitive of all imaging modalities in the early stages of the bone marrow infarct. Radionuclide imaging using 99mTc sulfur colloid shows sharply demarcated photon-deficient regions that are slow to resolve. Cumulative exposure to ionizing radiation would be of concern if repeated examinations with conventional x-rays and radionuclides were carried out. Magnetic resonance imaging (MRI) is a noninvasive technique that differentiates the bone marrow of sickle cell patients from that of normal controls. Furthermore, at least in some patients, acute tissue changes can be detected during early stages of pain crises using magnetic resonance. Further investigations are necessary to optimize the use of MRI in sickle cell patients with pain crises.
使用多种成像技术可以对有或没有疼痛危象的镰状细胞病患者的骨髓进行评估。在骨髓梗死的早期阶段，传统放射照相术是所有成像方式中最不敏感的。使用99mTc硫胶体的放射性核素成像显示出界限清晰的光子缺乏区域，这些区域消散缓慢。如果对传统X射线和放射性核素进行重复检查，累积电离辐射暴露将令人担忧。磁共振成像（MRI）是一种非侵入性技术，可区分镰状细胞病患者与正常对照者的骨髓。此外，至少在一些患者中，使用磁共振成像可以在疼痛危象的早期阶段检测到急性组织变化。有必要进行进一步研究，以优化MRI在有疼痛危象的镰状细胞病患者中的应用。
