颅脑创伤中血脑屏障功能障碍的机制。
Mechanisms of Blood-Brain Barrier Dysfunction in Traumatic Brain Injury.
机构信息
The Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA.
The Center for Regenerative Medicine, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA.
出版信息
Int J Mol Sci. 2020 May 8;21(9):3344. doi: 10.3390/ijms21093344.
Abstract
Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United States with roughly two million TBIs occurring annually. Due to the spectrum of severity and heterogeneity in TBIs, investigation into the secondary injury is necessary in order to formulate an effective treatment. A mechanical consequence of trauma involves dysregulation of the blood-brain barrier (BBB) which contributes to secondary injury and exposure of peripheral components to the brain parenchyma. Recent studies have shed light on the mechanisms of BBB breakdown in TBI including novel intracellular signaling and cell-cell interactions within the BBB niche. The current review provides an overview of the BBB, novel detection methods for disruption, and the cellular and molecular mechanisms implicated in regulating its stability following TBI.
摘要
创伤性脑损伤 (TBI) 在美国造成的与伤害相关的死亡中占大多数，每年约有 200 万例 TBI。由于 TBI 的严重程度和异质性范围广泛，因此有必要对继发性损伤进行调查，以便制定有效的治疗方法。创伤的一个机械后果是血脑屏障 (BBB) 的失调，这导致了继发性损伤和外周成分暴露于脑实质中。最近的研究揭示了 TBI 中 BBB 破裂的机制，包括 BBB 龛内新的细胞内信号和细胞-细胞相互作用。本综述提供了 BBB 的概述、用于检测破坏的新方法，以及在 TBI 后调节其稳定性的细胞和分子机制。
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