Many cities in the world are besieged by municipal solid waste (MSW). MSW not only pollutes the ecological environment but can even induce a series of public safety crises. Risk response for MSW needs novel changes. This paper innovatively adopts the ideas and methods of semantic web ontology to build an ontology-based reasoning system for MSW risk response. Through the integration of crisis information and case resources in the field of MSW, combined with the reasoning ability of Semantic Web Rule Language (SWRL), a system of rule reasoning for risk transformation is constructed. Knowledge extraction and integration of MSW risk response can effectively excavate semantic correlation of crisis information along with key transformation points in the process of crisis evolution through rule reasoning. The results show that rule reasoning of transformation can effectively improve intelligent decision-making regarding MSW risk response.