Extracorporeal membrane oxygenation and V/Q ratios: an ex vivo analysis of CO clearance within the Maquet Quadrox-iD oxygenator.

While hypercapnia is typically well treated with modern membrane oxygenators, there are cases where respiratory acidosis persists despite maximal extracorporeal membrane oxygenation support. To better understand the physiology of gas exchange within the membrane oxygenator, CO clearance within an adult Maquet Quadrox-iD oxygenator was evaluated at varying blood CO tensions and V/Q ratios in an ex vivo extracorporeal membrane oxygenation circuit. A closed blood-primed circuit incorporating two Maquet Quadrox-iD oxygenators in series was attached to a Maquet PLS Rotaflow pump. A varying blend of CO and air was connected to the first oxygenator to provide different levels of pre-oxygenator blood CO levels (PCO) to the second oxygenator. Varying sweep gas flows of 100% O were connected to the second oxygenator to provide different V/Q ratios. Exhaust CO was directly measured, and then VCO and oxygenator dead space fraction (V/V) were calculated. VCO increased with increasing gas flow rates with plateauing at V/Q ratios greater than 4.0. Exhaust CO increased with PCO in a linear fashion with the slope of the line decreasing at high V/Q ratios. Oxygenator dead space fraction varied with V/Q ratio-at lower ratios, dead space fraction was 0.3-0.4 and rose to 0.8-0.9 at ratios greater than 4.0. Within the Maquet Quadrox-iD oxygenator, CO clearance is limited at high V/Q ratios and correlated with elevated oxygenator dead space fraction. These findings have important implications for patients requiring high levels of extracorporeal membrane oxygenation support.