Maragalawaththa M G Sandeepanie K, Goyal Mandip
Medical Officer, Chamal Rajpraksha Ayurved Research Hospital, Hambantola, Srilanka.
Department of Kayachikitsa, IPGT & RA, Jamnagar, Gujarat, India.
Ayu. 2019 Apr-Jun;40(2):97-103. doi: 10.4103/ayu.AYU_65_18. Epub 2020 Mar 20.
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease caused by type III hypersensitivity reaction due to antigen antibody complexes which deposit at the joints resulting in arthritis. As per the concept of Ayurveda, it can be co-related with , the disease arising from deranged metabolism and vitiation. Despite of advancement in diagnostic approach of RA, management of it remains challenge. and are the formulations having analgesics properties due to their (metabolism enhancing) and (micro channel cleaning) and simultaneously possess anti-inflammatory properties.
To evaluate and compare the efficacy of and in the management of w.s.r. to rheumatoid arthritis.
For the present study, 58 patients were selected and divided into two groups. Patients of group A and group B were given and respectively with warm water after meal for one month. Before administration of trial drugs in both of groups' patients were given 4-6 grams of powder depending upon the of the patient, on empty stomach early morning for the purpose of (purgation) for 3 days. In addition to assess effect on signs and symptoms of , haematological investigation, biochemical investigation including quantitative C-reactive protein (CRP) and rheumatoid factor (RA factor) and routine urinary examination were carried out before and after treatment in all the registered patients. The effect of therapy was assessed on the basis of changes in score in comparison to end point score.
All the cardinal and associate complaints were statistically significant improved after the course of the trial drug. Most of the functional parameters had statistically significant improvement after treatment except left side foot pressure and DAS 28 scale in B group. Biochemical and hematological parameters were within normal limit before and after treatment. The difference of effect of trial drug on chief complaints was statistically insignificant. The difference of effect of trial drug on associate complaints was statistically insignificant. Difference of effect of trial drugs on ESR of both the groups was statistically insignificant. The difference of effect of trial drug on RA factor and CRP between groups was statistically significant. The difference of effect of trial drug on functional parameters between groups were statistically significant.
The study revealed that, though both the trial drugs; and are effective in the management of , but clinically is comparatively more effective than in the management of .
类风湿性关节炎（RA）是一种慢性炎症性自身免疫性疾病，由抗原抗体复合物引起的III型超敏反应所致，这些复合物沉积在关节处导致关节炎。根据阿育吠陀医学的概念，它可与因代谢紊乱和体质受损而引发的疾病相关联。尽管RA的诊断方法有所进步，但其治疗仍然具有挑战性。[药物名称1]和[药物名称2]因其具有促进（新陈代谢增强）和疏通（微通道清洁）作用而具有止痛特性，同时还具有抗炎特性。
评估并比较[药物名称1]和[药物名称2]在治疗类风湿性关节炎方面的疗效。
在本研究中，选取了58例患者并分为两组。A组和B组患者分别饭后用温水服用[药物名称1]和[药物名称2]，持续一个月。在两组患者服用试验药物前，根据患者体质，清晨空腹给予4 - 6克[泻药名称]粉末进行3天的泻下治疗。除了评估对类风湿性关节炎体征和症状的影响外，还对所有登记患者在治疗前后进行了血液学检查、生化检查，包括定量C反应蛋白（CRP）和类风湿因子（RA因子）以及常规尿液检查。根据与终点评分相比的分数变化来评估治疗效果。
在试验药物疗程结束后，所有主要和相关症状在统计学上均有显著改善。除了B组的左侧足部压力和DAS 28量表外，大多数功能参数在治疗后有统计学上的显著改善。治疗前后生化和血液学参数均在正常范围内。试验药物对主要症状的疗效差异在统计学上无显著意义。试验药物对相关症状的疗效差异在统计学上无显著意义。试验药物对两组血沉的疗效差异在统计学上无显著意义。试验药物对两组RA因子和CRP的疗效差异在统计学上有显著意义。试验药物对两组功能参数的疗效差异在统计学上有显著意义。
研究表明，虽然两种试验药物[药物名称1]和[药物名称2]在治疗类风湿性关节炎方面均有效，但在临床上[药物名称1]在治疗类风湿性关节炎方面比[药物名称2]更有效。
