Javaeed Arslaan, Ghauri Sanniya Khan, Ibrahim Abdellatif, Doheim Mohamed Fahmy
Poonch Medical College, Rawalakot, Pakistan.
Shifa International Hospital, Islamabad, Pakistan.
Oncol Rev. 2020 Apr 30;14(1):449. doi: 10.4081/oncol.2020.449. eCollection 2020 Feb 18.
Prostate-specific antigen velocity (PSAV) is widely used to detect PC and predict its progression. In this study, we qualitatively synthesized the currently available evidence from published studies regarding the PSAV role in PC. Electronic databases were searched to find relevant articles published until January 2019. Inclusion and exclusion criteria were applied to identify related papers. Eventually, data extraction followed by evidence synthesis was conducted. Full-text screening resulted in 42 included studies. Multiple definitions and intervals were used for PSAV calculation across studies. Results from the included studies were conflicting regarding the role of PSAV in detecting PC and predicting progression in active surveillance cases. However, there is evidence that PSAV may have a predictive role in post-treated men. There is no clear-cut evidence from the published literature to support the use of PSAV in clinical practice.
前列腺特异性抗原速度（PSAV）被广泛用于检测前列腺癌（PC）并预测其进展。在本研究中，我们定性合成了已发表研究中关于PSAV在PC中作用的现有证据。通过检索电子数据库以查找截至2019年1月发表的相关文章。应用纳入和排除标准来识别相关论文。最终，进行了数据提取并随后进行证据合成。全文筛选产生了42项纳入研究。各项研究中PSAV的计算使用了多种定义和区间。纳入研究的结果在PSAV在检测PC以及预测主动监测病例进展方面的作用上存在矛盾。然而，有证据表明PSAV可能对接受治疗后的男性具有预测作用。已发表的文献中没有明确的证据支持在临床实践中使用PSAV。
