Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China.
Dis Esophagus. 2020 Dec 7;33(12). doi: 10.1093/dote/doaa032.
A less invasive endoscopic therapy has been used as a routine treatment for superficial esophageal squamous cell carcinoma (SESCC). However, lymph node metastasis (LNM) in SESCC limits the effectiveness of this medical procedure. This meta-analysis aimed to screen the risk factors for LNM in SESCC in Asia to provide evidence for clinicians in selecting treatment. We searched the main reference databases for research involving patients who received esophagectomy (open or minimally invasive) with lymph node dissection for SESCC. Meta-analysis was performed using RevMan 5.3 software. Twenty studies including 3983 patients were obtained in this analysis. The meta-analysis showed that tumor size, macroscopic type of tumor, degree of differentiation, depth of tumor invasion, and lymphovascular involvement are risk factors of LNM in SESCC, whereas age, sex, and tumor location showed no association with LNM. Five variables were screened as predictive factors for LNM in SESCC. The incidence of LNM in SESCC is not rare, and the physicians must be careful when making clinical decisions.
内镜下治疗已被广泛应用于治疗早期食管鳞状细胞癌（SESCC）。然而，SESCC 的淋巴结转移（LNM）限制了该治疗方法的效果。本荟萃分析旨在筛选亚洲 SESCC 患者 LNM 的危险因素，为临床医生选择治疗方法提供依据。我们检索了主要的参考文献数据库，以获取接受食管切除术（开放或微创）和淋巴结清扫术治疗 SESCC 的患者的相关研究。使用 RevMan 5.3 软件进行荟萃分析。本分析共纳入 20 项研究，共计 3983 例患者。荟萃分析显示，肿瘤大小、肿瘤大体类型、分化程度、肿瘤浸润深度和脉管侵犯是 SESCC 患者发生 LNM 的危险因素，而年龄、性别和肿瘤部位与 LNM 无关。筛选出 5 个变量作为 SESCC 患者发生 LNM 的预测因素。SESCC 患者的 LNM 发生率并不少见，临床医生在做出决策时应谨慎。
