Długońska H, Chmiela M, Kierońska D, Rózałska B, Rudnicka W
Department of Immunology, University of Lódź.
Arch Immunol Ther Exp (Warsz). 1988;36(2):151-9.
The work was designated to compare the influence of an active immunization on the expression of anti-listerial resistance of relatively resistant to listeriosis C57B1/6 mice as compared with more susceptible to the infection DBA/2 mice. Although, specific immunization of DBA/2 mice enhanced their anti-listerial resistance but immunized DBA/2 mice still eliminated Listeria rods less effectively than immunized C57B1/6 mice. It means that innate difference in anti-listerial resistance between C57B1/6 and DBA/2 mice was maintained after immunizing them with the same number of alive bacteria. Greater anti-listerial resistance of C57B1/6 versus DBA/2 mice is associated with an increased accumulation of inflammatory Ms and PMNs in their peritonea and an increased capacity of their PMNs to restrict Listeria growth.
这项工作旨在比较主动免疫对相对抗李斯特菌病的C57B1/6小鼠与更易感染的DBA/2小鼠抗李斯特菌抗性表达的影响。尽管对DBA/2小鼠进行特异性免疫增强了它们的抗李斯特菌抗性，但免疫后的DBA/2小鼠清除李斯特菌杆状菌的效果仍不如免疫后的C57B1/6小鼠。这意味着在用相同数量的活细菌免疫后，C57B1/6和DBA/2小鼠之间抗李斯特菌抗性的先天差异仍然存在。C57B1/6小鼠相对于DBA/2小鼠具有更强的抗李斯特菌抗性，这与它们腹膜中炎性Ms和PMN的积累增加以及PMN限制李斯特菌生长的能力增强有关。
