Innate anti-listerial resistance of mice differing in their susceptibility to listeriosis.

The work was designated to compare the influence of an active immunization on the expression of anti-listerial resistance of relatively resistant to listeriosis C57B1/6 mice as compared with more susceptible to the infection DBA/2 mice. Although, specific immunization of DBA/2 mice enhanced their anti-listerial resistance but immunized DBA/2 mice still eliminated Listeria rods less effectively than immunized C57B1/6 mice. It means that innate difference in anti-listerial resistance between C57B1/6 and DBA/2 mice was maintained after immunizing them with the same number of alive bacteria. Greater anti-listerial resistance of C57B1/6 versus DBA/2 mice is associated with an increased accumulation of inflammatory Ms and PMNs in their peritonea and an increased capacity of their PMNs to restrict Listeria growth.