Faculty of Medicine, Department of Medical Biology, Cumhuriyet University, Sivas, Turkey.
Faculty of Medicine, Department of Medical Biochemistry, Cumhuriyet University, Sivas, Turkey.
J Obstet Gynaecol. 2020 May;40(4):495-499. doi: 10.1080/01443615.2019.1634017. Epub 2019 Sep 17.
Preeclampsia (PE), which occurs in approximately 5% of pregnancies worldwide and constitutes clinically serious complications in 2-3%, is one of the leading causes of maternal and prenatal morbidity and mortality. Recent studies report that regulatory T (Treg) cells, which act as immunosuppressant, are associated with PE. It is clearly defined that /Scurfin (Forkhead Box P3) is involved in the development and function of Tregs. However, there are different conclusions regarding the relationship between PE and gene polymorphisms for different populations. For this reason, in this study we investigate the association between gene promoter region polymorphisms and PE in a Turkish population 500 PE patients and 500 healthy pregnant women. Blood samples taken from pregnant women were studied by PCR-RFLP method. As a result, rs2232365 polymorphism was significantly associated with disease ( < .0001) while no significant association was found between rs3761548 polymorphism and the disease ( = .17). Based on these results, it is though that rs2232365 polymorphism may be predisposed to PE development in terms of Turkish population. However, further and functional studies are needed in terms of other polymorphisms and mutations.IMPACT STATEMENT A number of recent publications suggest that Tregs may play a role in the pathogenesis of PE. It is known that a stable and high expression is required to maintain the suppressive T cell function of Tregs. Down regulation of in PE has been reported in many previous studies, but the mechanism is still uncertain. Our study has examined two promoter region polymorphisms in terms of Turkish population for the first time. Rs2232365 polymorphism associated with the disease in heterozygous genotype. It has been shown that gene promoter region polymorphisms may be associated with PE for Turkish population. Our results can be a guide for more detailed statistical evaluations and functional studies.
子痫前期（PE）在全球约 5%的妊娠中发生，在 2-3%的病例中构成严重的临床并发症，是孕产妇和围生期发病率和死亡率的主要原因之一。最近的研究报告表明，调节性 T（Treg）细胞作为免疫抑制剂与 PE 有关。显然，/Scurfin（叉头框 P3）参与了 Treg 的发育和功能。然而，对于不同人群，PE 与基因多态性之间的关系存在不同的结论。出于这个原因，在这项研究中，我们在土耳其人群中研究了基因启动子区域多态性与 PE 之间的关系，该人群包括 500 名 PE 患者和 500 名健康孕妇。从孕妇采集的血液样本通过 PCR-RFLP 方法进行研究。结果，rs2232365 多态性与疾病显着相关（<0.0001），而 rs3761548 多态性与疾病之间无显着关联（=0.17）。基于这些结果，认为 rs2232365 多态性可能易患土耳其人群的 PE 发展。然而，需要针对其他多态性和突变进行进一步和功能研究。
最近的一些出版物表明，Treg 可能在 PE 的发病机制中起作用。已知需要稳定和高表达才能维持 Treg 的抑制性 T 细胞功能。许多先前的研究已经报道了 PE 中下调，但机制仍不确定。我们的研究首次针对土耳其人群检查了两个基因启动子区域多态性。杂合基因型中 rs2232365 多态性与疾病相关。已经表明，基因启动子区域多态性可能与土耳其人群的 PE 相关。我们的结果可以为更详细的统计评估和功能研究提供指导。
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