Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Xi'an, China.
Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
J Cell Physiol. 2020 Dec;235(12):9121-9132. doi: 10.1002/jcp.29782. Epub 2020 May 13.
Chemokines constitute a superfamily of small chemotactic cytokines with functions that are based on interactions with their corresponding receptors. It has been found that, among other functions, chemokines regulate the migratory and invasive abilities of cancer cells. Multiple studies have confirmed that chemokine receptor 9 (CCR9) and its exclusive ligand, chemokine 25 (CCL25), are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This review evaluates recent advances in understanding the role of CCR9/CCL25 in cancer development. First, we outline the general background of chemokines in cancer and the structure and function of CCR9 and CCL25. Next, we describe the basic function of CCR9/CCL25 in the cancer process. Then, we introduce the role of CCR9/CCL25 and related signaling pathways in various cancers. Finally, future research directions are proposed. In general, this paper is intended to serve as a comprehensive repository of information on this topic and is expected to contribute to the design of other research projects and future efforts to develop treatment strategies for ameliorating the effects of CCR9/CCL25 in cancer.
趋化因子构成了一个小的趋化细胞因子的超家族，其功能基于与相应受体的相互作用。已经发现，趋化因子除了其他功能外，还调节癌细胞的迁移和侵袭能力。多项研究证实，趋化因子受体 9（CCR9）及其特异性配体趋化因子 25（CCL25）在多种恶性肿瘤中过度表达，并与肿瘤增殖、凋亡、侵袭、迁移和耐药密切相关。本综述评估了近年来对 CCR9/CCL25 在癌症发展中作用的认识进展。首先，我们概述了趋化因子在癌症中的一般背景，以及 CCR9 和 CCL25 的结构和功能。接下来，我们描述了 CCR9/CCL25 在癌症过程中的基本功能。然后，我们介绍了 CCR9/CCL25 及其相关信号通路在各种癌症中的作用。最后，提出了未来的研究方向。总的来说，本文旨在作为该主题的综合信息库，预计将有助于设计其他研究项目，并为未来努力制定治疗策略以减轻 CCR9/CCL25 在癌症中的作用。
