Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Radiology, Faculty of Paramedical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran.
J Med Eng Technol. 2020 May;44(4):162-168. doi: 10.1080/03091902.2020.1757771. Epub 2020 May 13.
In Iran, breast cancer (BC) is the most prevalent cancer among women. The standard treatment for this cancer is partial or total removal of breast tissue, followed by chemotherapy and radiation. Tissue engineering (TE) has made new treatments for tissue loss in these patients by creating functional substitutes in the laboratory. In addition, cancer biology combined with TE provides a new strategy for evaluation of anti-BC therapy. Several innovations in TE have led to the design of scaffold or matrix based culture systems that more closely mimic the native extracellular matrix (ECM). Currently, engineered three-dimensional (3D) cultures are being developed for modelling of the tumour microenvironment. These 3D cultures fulfil the need for approaches that allow an accurate study of the molecular mechanisms and a better analysis of the drugs effect. In the present study, we review recent developments in utilising of TE in BC. Moreover, this review describes achievements of Iranian researchers in the field of breast TE.
在伊朗，乳腺癌（BC）是女性中最常见的癌症。这种癌症的标准治疗方法是部分或全部切除乳房组织，然后进行化疗和放疗。组织工程（TE）通过在实验室中创建功能性替代品，为这些患者的组织缺失提供了新的治疗方法。此外，癌症生物学与 TE 的结合为评估抗乳腺癌治疗提供了新的策略。TE 的几项创新导致了支架或基质为基础的培养系统的设计，这些系统更能模拟天然细胞外基质（ECM）。目前，正在开发工程化的三维（3D）培养物来模拟肿瘤微环境。这些 3D 培养物满足了人们对方法的需求，这些方法可以准确研究分子机制，并更好地分析药物的作用。在本研究中，我们回顾了利用 TE 治疗 BC 的最新进展。此外，本综述还描述了伊朗研究人员在乳房 TE 领域的成就。
