Department of Rheumatology and Immunology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Department of Radiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Braz J Med Biol Res. 2020;53(6):e9118. doi: 10.1590/1414-431x20209118. Epub 2020 May 8.
This study aimed to investigate the predictive factors for uveitis recurrence (UR) risk in Behcet's disease (BD) patients. BD patients (n=164) with a history of uveitis were recruited, and demographic data, clinical features, and laboratory tests were recorded. Uveitis was defined as anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis referring to the "International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease". In total, there were 70 UR patients and 94 non-UR patients. Compared to non-UR patients, UR patients appeared to be older and presented with increased uveitis occurrence rate and times within 3 months, oral ulcers occurrence rate, as well as higher concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and serum amyloid A (SAA). Multivariate logistic model disclosed that uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA independently predicted higher risk of UR. Furthermore, receiver operating characteristic curve analysis showed that the combination of uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA exhibited a high predictive value for UR risk with an area under the curve of 0.983 (95%CI: 0.969-0.998). In conclusion, uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA might be potential predictive factors for UR risk in BD patients, which can help in prevention and management of the disease.
本研究旨在探讨 Behcet 病（BD）患者葡萄膜炎复发（UR）风险的预测因素。招募了 164 例有葡萄膜炎病史的 BD 患者，并记录了人口统计学数据、临床特征和实验室检查。葡萄膜炎定义为前葡萄膜炎、中间葡萄膜炎、后葡萄膜炎、全葡萄膜炎，参考“国际葡萄膜炎研究组对眼内炎症性疾病评估的建议”。共有 70 例 UR 患者和 94 例非 UR 患者。与非 UR 患者相比，UR 患者年龄较大，3 个月内葡萄膜炎发生率和次数、口腔溃疡发生率以及甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）和血清淀粉样蛋白 A（SAA）浓度较高。多变量逻辑模型显示，3 个月内葡萄膜炎发生次数、口腔溃疡、TG、LDL 和 SAA 独立预测 UR 风险增加。此外，受试者工作特征曲线分析显示，3 个月内葡萄膜炎发生次数、口腔溃疡、TG、LDL 和 SAA 的组合对 UR 风险具有较高的预测价值，曲线下面积为 0.983（95%CI：0.969-0.998）。总之，3 个月内葡萄膜炎发生次数、口腔溃疡、TG、LDL 和 SAA 可能是 BD 患者 UR 风险的潜在预测因素，有助于疾病的预防和管理。
