Desi S B, Ruszkiewicz M
Transplantation. 1977 Mar;23(3):230-8. doi: 10.1097/00007890-197703000-00005.
Lewis rats that were given injections of 10(6) to 10(8) (Lewis X Brown Norway) F1 hybrid bone marrow cells produce predominantly, if not exclusively, 19S lymphocytotoxic antibodies. A number of Lewis rats that received transplants of perfused renal allografts from bone marrow donors at, or near, the peak of IgM response survival for well over 200 days with good renal function and no histological evidence of chronic rejection. All long-surviving rats had detectable lymphocytotoxic antibodies up to 120 days after allografting; late enhancing antibodies had the restricted specificity possibly identical or similar to anti-I region antisera. All rats bearing prolonged renal allografts were unable to accept donor-specific skin grafts or to respond with specific lymphocytotoxic antibodies following skin grafting. The possible involvement of non-complement-fixing 19S alloantibodies in active enhancement of rat renal allografts is discussed.
给Lewis大鼠注射10⁶至10⁸个（Lewis×棕色挪威大鼠）F1杂交骨髓细胞后，主要（如果不是唯一的话）产生19S淋巴细胞毒性抗体。一些Lewis大鼠在IgM反应高峰期或接近高峰期接受来自骨髓供体的灌注肾同种异体移植后，肾功能良好，存活超过200天，且无慢性排斥的组织学证据。所有长期存活的大鼠在同种异体移植后120天内均可检测到淋巴细胞毒性抗体；晚期增强抗体具有受限的特异性，可能与抗I区抗血清相同或相似。所有长期存活肾同种异体移植的大鼠均不能接受供体特异性皮肤移植，也不能在皮肤移植后产生特异性淋巴细胞毒性抗体。本文讨论了非补体结合19S同种异体抗体可能参与大鼠肾同种异体移植的主动增强作用。
