镥-177 锡胶体与锝-188 锡胶体放射性滑膜切除术治疗慢性膝关节关节炎的比较。
Comparison of Lutetium-177 tin colloid and Rhenium-188 tin colloid radiosynovectomy in chronic knee arthritis.
机构信息
Departments of Nuclear Medicine.
Orthopedics.
出版信息
Nucl Med Commun. 2020 Aug;41(8):721-726. doi: 10.1097/MNM.0000000000001210.
OBJECTIVE
To assess the role of Lutetium-177(Lu-177) tin colloid for radiosynovectomy and compare it with Rhenium-188 (Re-188) tin colloid radiosynovectomy for alleviation of pain in patients with chronic inflammatory arthritis of knee.
METHODS
Patients of chronic inflammatory arthritis of the knee underwent pretherapeutic evaluation in a form of knee ultrasonogram, bone scan and clinical evaluation. Fifty-seven recruited patients were allocated at random to receive either intraarticular injections of Lu-177 tin colloid or Re-188 tin colloid. Eventually, 27 patients received Re-188 tin colloid and 30 patients received Lu-177 tin colloid. The joint was then immobilized for 2 days. Response evaluation was done using knee ultrasound, bone scan and clinical findings.
RESULT
Of 30, 20 patients responded to radiosynovectomy in the Lu-177 tin colloid group compared to 21/27 patients in the Re-188 tin colloid group.
CONCLUSION
Lu-177 tin colloid is an effective alternative to Re-188 tin colloid for radiosynovectomy in patients with chronic inflammatory knee arthritis.
目的
评估镥-177（Lu-177）锡胶体在放射性滑膜切除术中的作用，并将其与放射性滑膜切除术中的锝-188（Re-188）锡胶体进行比较，以缓解膝关节慢性炎症性关节炎患者的疼痛。
方法
膝关节慢性炎症性关节炎患者以膝关节超声、骨扫描和临床评估的形式进行治疗前评估。招募的 57 名患者被随机分配接受关节内注射 Lu-177 锡胶体或 Re-188 锡胶体。最终，27 名患者接受 Re-188 锡胶体，30 名患者接受 Lu-177 锡胶体。然后将关节固定 2 天。使用膝关节超声、骨扫描和临床发现进行反应评估。
结果
在 Lu-177 锡胶体组中，30 名患者中有 20 名对放射性滑膜切除术有反应，而 Re-188 锡胶体组中有 21/27 名患者有反应。
结论
Lu-177 锡胶体是治疗慢性炎症性膝关节关节炎患者放射性滑膜切除术的有效替代物。
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