间变性大细胞淋巴瘤中间变性淋巴瘤激酶阳性的 FDG PET/CT

FDG PET/CT in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma.

机构信息

From the Division of Diagnostic Nuclear Medicine, Department of Nuclear Medicine.

Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Clin Nucl Med. 2020 Jul;45(7):540-541. doi: 10.1097/RLU.0000000000003071.

DOI:10.1097/RLU.0000000000003071

PMID:32404708

Abstract

Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin's lymphoma, with rearrangements of the anaplastic lymphoma kinase gene in 60%-85% of systemic cases. We report an 11-year-old boy with ALCL in whom serial FDG PET/CT revealed partial response and complete metabolic response at interim and end of treatment, respectively. However, the patient relapsed within 2 weeks, confirmed by cytology. Because of the inherent aggressive nature of ALCL, possibility of an early relapse should always be kept in mind.

摘要

间变性大细胞淋巴瘤（ALCL）是一种罕见的非霍奇金淋巴瘤，60%-85%的系统性病例存在间变性淋巴瘤激酶基因重排。我们报告了一例 11 岁男孩的 ALCL 病例，其连续的 FDG PET/CT 分别在治疗中期和结束时显示部分缓解和完全代谢缓解。然而，患者在 2 周内复发，细胞学检查证实了这一点。由于 ALCL 的固有侵袭性，应始终牢记早期复发的可能性。