GenPop——一个用于分析人类群体遗传数据的在线工具。
GenPop-An Online Tool to Analyze Human Population Genetic Data.
作者信息
Mahesh B Arundhati, Kannan E, Davis G Dicky John, Venkatesan P, Ragunath P K
机构信息
Department of Bioinformatics, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai ,Tamilnadu, India- 600116.
VelTech Rangarajan Dr. Saguthala R&D Institute of Science and Technology, Avadi, Chennai ,Tamilnadu, India - 600062.
出版信息
Bioinformation. 2020 Feb 29;16(2):149-152. doi: 10.6026/97320630016149. eCollection 2020.
GenPop is a web based online cross platform tool developed to help Geneticist and Epidemiologist to deal with association studies in analyzing human population genetic data. The tool features include descriptive analysis such as Hardy-Weinberg equilibrium test, chi-square p-value and analysis of single nucleotide polymorphisms (SNPs) with multiple inheritance models such as dominant, recessive, allelic, genotype, odd's ratio and relative risk at 95% confidence interval and analysis of multiple SNPs including haplotype frequencies and linkage disequilibrium for a pair of biallelic markers. This is a user-driven human population genetic data analysis tool that is easily scalable and acceptable with multiple implementations of different algorithms. GenPop has been developed using PHP, JavaScript and with PHPExcel library to analyse the genetic data for case control studies.
GenPop是一个基于网络的在线跨平台工具，旨在帮助遗传学家和流行病学家在分析人类群体遗传数据时处理关联研究。该工具的功能包括描述性分析，如哈迪-温伯格平衡检验、卡方p值，以及对单核苷酸多态性（SNP）的分析，采用多种遗传模型，如显性、隐性、等位基因、基因型、优势比和95%置信区间的相对风险，还包括对多个SNP的分析，如一对双等位基因标记的单倍型频率和连锁不平衡。这是一个用户驱动的人类群体遗传数据分析工具，易于扩展，并且能够接受不同算法的多种实现方式。GenPop是使用PHP、JavaScript以及PHPExcel库开发的，用于分析病例对照研究的遗传数据。
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