Anitha P, Kumar Praveen K, Shanmughavel P, Nazeema T H, Lalitha G
Department of Biochemistry, Rathnavel Subramaniam College of Arts and Science, Coimbatore, Tamilnadu,India.
Department of Bioinformatics, Bharathiar University, Coimbatore, Tamilnadu,India.
Bioinformation. 2020 Feb 29;16(2):189-195. doi: 10.6026/97320630016189. eCollection 2020.
The autoinhibited Parkin catalytic domain (PDB ID: 4BM9) receptor has been described to have a role in the ubiquitination of α-syn in Parkinson's disease. Therefore, it is of interest to discuss the molecular docking analysis data of phytochemicals from ethanolic extract of Crescentia cujete with the auto inhibited Parkin catalytic domain. We report the docking features of the phytochemical named 1, 2-Ethanediamine, N-(2-aminoethyl) with the target protein for further consideration towards the design and development of anti-Parkinson agents.
自抑制型帕金森蛋白催化结构域（蛋白质数据银行ID：4BM9）受体已被描述在帕金森病中α-突触核蛋白的泛素化过程中发挥作用。因此，探讨来自葫芦树乙醇提取物的植物化学物质与自抑制型帕金森蛋白催化结构域的分子对接分析数据很有意义。我们报告了名为1,2-乙二胺，N-（2-氨基乙基）的植物化学物质与靶蛋白的对接特征，以供进一步考虑抗帕金森病药物的设计与开发。
