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心脏手术后再次开胸的发病率和影响对发病率和死亡率的影响:代表心胸麻醉和危重病协会进行的为期 1 年的全国审计。

The incidence and effect of resternotomy following cardiac surgery on morbidity and mortality: a 1-year national audit on behalf of the Association of Cardiothoracic Anaesthesia and Critical Care.

机构信息

Department of Anaesthesia, Manchester University Hospitals, Manchester, UK.

Department of Anaesthesiology, University of Hong Kong.

出版信息

Anaesthesia. 2021 Jan;76(1):19-26. doi: 10.1111/anae.15070. Epub 2020 May 13.

DOI:10.1111/anae.15070
PMID:32406071
Abstract

Over 30,000 adult cardiac operations are carried out in the UK annually. A small number of these patients need to return to theatre in the first few days after the initial surgery, but the exact proportion is unknown. The majority of these resternotomies are for bleeding or cardiac tamponade. The Association of Cardiothoracic Anaesthesia and Critical Care carried out a 1-year national audit of resternotomy in 2018. Twenty-three of the 35 centres that were eligible participated. The overall resternotomy rate (95%CI) within the period of admission for the initial operation in these centres was 3.6% (3.37-3.85). The rate varied between centres from 0.69% to 7.6%. Of the 849 patients who required resternotomy, 127 subsequently died, giving a mortality rate (95%CI) of 15.0% (12.7-17.5). In patients who underwent resternotomy, the median (IQR [range]) length of stay on ICU was 5 (2-10 [0-335]) days, and time to tracheal extubation was 20 (12-48 [0-2880]) hours. A total of 89.3% of patients who underwent resternotomy were transfused red cells, with a median (IQR [range]) of 4 (2-7 [1-1144]) units of red blood cells. The rate (95%CI) of needing renal replacement therapy was 23.4% (20.6-26.5). This UK-wide audit has demonstrated that resternotomy after cardiac surgery is associated with prolonged intensive care stay, high rates of blood transfusion, renal replacement therapy and very high mortality. Further research into this area is required to try to improve patient care and outcomes in patients who require resternotomy in the first 24 h after cardiac surgery.

摘要

英国每年进行超过 30,000 例成人心脏手术。一小部分患者在初始手术后的头几天需要返回手术室,但具体比例尚不清楚。这些再开胸手术大多数是为了出血或心脏压塞。心胸麻醉与危重病协会于 2018 年对再开胸手术进行了为期 1 年的全国性审计。有资格的 35 个中心中有 23 个参与了该研究。在这些中心初次手术入院期间,总的再开胸手术率(95%CI)为 3.6%(3.37-3.85)。中心之间的比率从 0.69%到 7.6%不等。在需要再开胸手术的 849 名患者中,有 127 人随后死亡,死亡率(95%CI)为 15.0%(12.7-17.5)。在接受再开胸手术的患者中,ICU 中位(IQR [范围])住院时间为 5(2-10 [0-335])天,气管拔管时间为 20(12-48 [0-2880])小时。接受再开胸手术的患者中,89.3%的患者需要输注红细胞,中位数(IQR [范围])为 4(2-7 [1-1144])单位红细胞。需要肾脏替代治疗的比例(95%CI)为 23.4%(20.6-26.5)。这项英国范围内的审计表明,心脏手术后再开胸手术与 ICU 住院时间延长、输血率高、肾脏替代治疗和极高的死亡率相关。需要进一步研究这一领域,以努力改善心脏手术后 24 小时内需要再开胸手术的患者的护理和结果。

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