Laboratory for Studies in Biomedical Engineering and Health, Federal University of Technology, Curitiba, Brazil.
Angelina Caron Hospital, Campina Grande, Brazil.
Gynecol Endocrinol. 2020 Jul;36(7):578-581. doi: 10.1080/09513590.2020.1762558. Epub 2020 May 14.
: To analyze the effects of body weight loss on bone mineral density (BMD) on hip (Hip BMD) and lumbar spine (Lumbar BMD) after six months of bariatric surgery. Bariatric surgery is an effective treatment for morbid obesity. Nonetheless, there are scant data on the effect of weight bearing on bone structure.: Seventeen obese women aged 41.2 ± 11.3 yrs. who underwent Roux-en-Y gastric bypass (RYGB) were included. Body composition assessments were performed through dual-energy X-ray absorptiometry immediately before and after 6-months RYGB. Data collected pre- and post-RYGB included total body weight, body mass index (BMI), lean body mass (LM), fat mass (FM) and bone mineral content. The pre- (PRE) and post-operative (POST) results were compared.: Lumbar BMD POST presented a non-significant loss of 1.8% whereas Hip BMD POST showed a significant loss of 17.8%. The analysis demonstrated that BMI and LM PRE explained 26% and 49%, respectively, of Hip BMD PRE variability. In addition, LM POST explained 30% of hip BMD POST variability and was not significant for Lumbar BMD POST.: Obesity and rapid weight loss showed direct influence in Hip BMD after six months of bariatric surgery. However, its effect on the lumbar spine area was smaller due to the higher capacity of the spine to dissipate loads through its curvature.
: 分析肥胖症患者接受减重手术后 6 个月时体重减轻对髋部（髋部骨密度，BMD）和腰椎（腰椎 BMD）骨矿物质密度的影响。减重手术是治疗病态肥胖症的有效方法。然而，目前关于承重对骨骼结构影响的数据很少。: 本研究纳入了 17 名年龄为 41.2±11.3 岁的肥胖女性，均接受了 Roux-en-Y 胃旁路术（RYGB）。通过双能 X 射线吸收法（DEXA）在 RYGB 手术前和手术后 6 个月时对身体成分进行评估。在 RYGB 手术前后收集的数据包括总体重、体重指数（BMI）、瘦体重（LM）、体脂肪量（FM）和骨矿物质含量。比较 RYGB 手术前后的结果。: 腰椎 BMD 术后出现无统计学意义的 1.8%的损失，而髋部 BMD 术后则出现显著的 17.8%的损失。分析表明，BMI 和 LM 术前分别解释了髋部 BMD 术前变异性的 26%和 49%。此外，LM 术后解释了髋部 BMD 术后变异性的 30%，但对腰椎 BMD 术后变异性没有显著影响。: 肥胖和体重快速下降直接影响肥胖症患者接受减重手术后 6 个月时的髋部 BMD。然而，由于脊柱通过其曲率消散负荷的能力较高，其对腰椎区域的影响较小。
