Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Ren Fail. 2020 Nov;42(1):455-462. doi: 10.1080/0886022X.2020.1762646.
Vascular calcification (VC) is an important promoter of cardiovascular disease (CVD) in patients undergoing peritoneal dialysis (PD). Several indices can be used to evaluate VC, including the abdominal aortic calcification index (AACI) and carotid artery intima-media thickness (IMT); however, simpler and lesser expensive predictors, such as the radial augmentation index (RAI), should be investigated. A total of 101 patients undergoing PD were recruited to measure RAI, AACI, and carotid artery IMT and perform echocardiography. Fifty healthy controls (HCs) were recruited to undergo RAI measurement. RAI in patients undergoing PD was significantly higher than the RAI in HCs (86.25%±8.39% vs. 76.05%±9.81%, < 0.05). Patients undergoing PD and who suffer with diabetic mellitus, hypertension, and CVD had more severe VC than those without the abovementioned diseases. In patients with PD, RAI was positively correlated with AACI ( = 0.671, < 0.05) and carotid artery IMT ( = 0.596, < 0.05). RAI was positively correlated with left ventricular end-diastolic dimensions (LVDd; = 0.678, < 0.05), left ventricular mass index ( = 0.595, < 0.05), and negatively correlated with early-diastolic mitral inflow velocity/late-diastolic mitral inflow velocity ( = -0.342, < 0.05) and left ventricular ejection fraction (= -0.497, < 0.05). Multiple linear regression analysis showed that RAI was associated with AACI, LVDd, age, and serum phosphate ( < 0.05). RAI might be an effective predictor of VC and cardiac structural/functional abnormalities in patients undergoing PD.
血管钙化（VC）是腹膜透析（PD）患者心血管疾病（CVD）的重要促进因素。有几种指数可用于评估 VC，包括腹主动脉钙化指数（AACI）和颈动脉内膜中层厚度（IMT）；然而，应该研究更简单、更经济的预测因子，如桡动脉增强指数（RAI）。共招募了 101 名接受 PD 的患者来测量 RAI、AACI 和颈动脉 IMT 并进行超声心动图检查。招募了 50 名健康对照者（HCs）进行 RAI 测量。接受 PD 的患者的 RAI 明显高于 HCs 的 RAI（86.25%±8.39%对 76.05%±9.81%， < 0.05）。患有糖尿病、高血压和 CVD 的 PD 患者的 VC 比没有上述疾病的患者更严重。在 PD 患者中，RAI 与 AACI 呈正相关（ = 0.671， < 0.05）和颈动脉 IMT（ = 0.596， < 0.05）。RAI 与左心室舒张末期内径（LVDd； = 0.678， < 0.05）和左心室质量指数（ = 0.595， < 0.05）呈正相关，与舒张早期二尖瓣血流速度/舒张晚期二尖瓣血流速度（ = -0.342， < 0.05）和左心室射血分数（= -0.497， < 0.05）呈负相关。多元线性回归分析显示，RAI 与 AACI、LVDd、年龄和血清磷酸盐有关（ < 0.05）。RAI 可能是 PD 患者 VC 和心脏结构/功能异常的有效预测因子。
