Laboratory of Pediatric Physical Activity, Infant Center, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Laboratory of Cellular Biophysics and Inflammation, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do SulCEP 90619-900, Brazil.
J Dev Orig Health Dis. 2021 Apr;12(2):271-279. doi: 10.1017/S2040174420000343. Epub 2020 May 14.
Stressful events during the prenatal period have been related to hyperactive hypothalamic-pituitary-adrenal (HPA) axis responses as well as metabolic changes in adult life. Moreover, regular exercise may contribute to the improvement of the symptoms associated with stress and stress-related chronic diseases. Therefore, this study aims to investigate the effects of exercise, before the gestation period, on the metabolic changes induced by prenatal stress in adult mice. Female Balb/c mice were divided into three groups: control (CON), prenatal restraint stress (PNS) and exercise before the gestational period plus PNS (EX + PNS). When adults, the plasmatic biochemical analysis, oxidative stress, gene expression of metabolic-related receptors and sex differences were assessed in the offspring. Prenatal stress decreased neonatal and adult body weight when compared to the pregestational exercise group. Moreover, prenatal stress was associated with reduced body weight in adult males. PNS and EX + PNS females showed decreased hepatic catalase. Pregestational exercise prevented the stress-induced cholesterol increase in females but did not prevent the liver mRNA expression reduction on the peroxisome proliferator-activated receptors (PPARs) α and γ in PNS females. Conversely, PNS and EX + PNS males showed an increased PPARα mRNA expression. In conclusion, pregestational exercise prevented some effects of prenatal stress on metabolic markers in a sex-specific manner.
孕期应激事件与下丘脑-垂体-肾上腺（HPA）轴反应过度以及成年后的代谢变化有关。此外，有规律的运动可能有助于改善与应激和应激相关的慢性疾病相关的症状。因此，本研究旨在探讨孕期前运动对成年小鼠产前应激引起的代谢变化的影响。将雌性 Balb/c 小鼠分为三组：对照组（CON）、产前束缚应激组（PNS）和孕期前运动加产前束缚应激组（EX+PNS）。当成年后，评估后代的血浆生化分析、氧化应激、代谢相关受体的基因表达和性别差异。与预孕期运动组相比，产前应激导致新生鼠和成年鼠体重下降。此外，产前应激与成年雄性体重下降有关。PNS 和 EX+PNS 雌性的肝过氧化氢酶减少。预孕期运动可预防应激引起的雌性胆固醇增加，但不能预防 PNS 雌性肝脏过氧化物酶体增殖物激活受体（PPARs）α和γ的 mRNA 表达减少。相反，PNS 和 EX+PNS 雄性的 PPARα mRNA 表达增加。总之，预孕期运动以性别特异性的方式预防了一些产前应激对代谢标志物的影响。
