Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Acta Oncol. 2020 Sep;59(9):1131-1136. doi: 10.1080/0284186X.2020.1759822. Epub 2020 May 14.
We aimed to review systematically the literature on locoregional recurrence rates in patients with HPV-positive and -negative oropharyngeal squamous cell carcinoma (OPSCC). PubMed and Embase databases were systematically searched using key words such as human papillomavirus, oropharyngeal squamous cell carcinoma with local, regional, and locoregional recurrence. Nine studies (2974 patients with known HPV-status, 59% HPV-positive) were included. Among the HPV-positive and -negative patients, 69% and 58% had lymph node metastasis at diagnosis. At a median time to recurrence ranging from 8.4 to 13.2 months among the included studies, we found that a weighted average of 9% and 26% for HPV-positive and -negative patients experienced locoregional recurrence. Overall, the median follow-up time ranged from 21 to 83 months among the included studies. Recurrence rates for HPV-positive and -negative OPSCC patients were 9% and 26%, respectively, equating to an almost three times higher rate of locoregional recurrence among HPV-negative patients compared to HPV-positive patients.
我们旨在系统地回顾人乳头瘤病毒（HPV）阳性和阴性口咽鳞状细胞癌（OPSCC）患者局部区域复发率的文献。使用“人乳头瘤病毒”、“HPV 阳性的口咽鳞状细胞癌伴局部、区域和局部区域复发”等关键词，对 PubMed 和 Embase 数据库进行了系统检索。共纳入 9 项研究（2974 例已知 HPV 状态患者，HPV 阳性率为 59%）。在 HPV 阳性和阴性患者中，69%和 58%在诊断时存在淋巴结转移。在纳入研究的中位复发时间为 8.4 至 13.2 个月之间，我们发现 HPV 阳性和阴性患者的局部区域复发率分别为 9%和 26%。总体而言，纳入研究的中位随访时间为 21 至 83 个月。HPV 阳性和阴性 OPSCC 患者的复发率分别为 9%和 26%，这意味着 HPV 阴性患者的局部区域复发率几乎是 HPV 阳性患者的三倍。
